Background: The present study investigated the deleterious effects on behavior in albino rats, including motor coordination abilities and overall activity. Deltamethrin is a commonly used synthetic pyrethroid insecticide, so understanding its potential effects on both humans and animals is crucial for ensuring safety in agricultural, residential, and public health settings. Comprehensive studies on its toxicological and behavioral impacts can contribute to risk assessments, regulatory decisions, and the development of safety guidelines and mitigation strategies.
Methods: Deltamethrin was administered intraperitoneal in
adult wistar albino rats (250- 270 gm), in the dose of 0.5 mg/kg/ body weight
for a month. All rats were observed for behavioral and toxicological symptoms.
Body weight and rectal temperature were measured. The open field behavior,
social interaction test, landing foot splay, and forelimb and hindlimb grip
test for neuromuscular function were done.
Results: Present study showed reduced locomotors activity
but not motor coordination. In this respect, the most important response to
increased emotionality in the open field is freezing behavior, with a
consequent decrease in locomotion frequency parallel to an increase in
immobility. Experimental rats showed signs of mild to moderate variety of
behavior and toxicological symptoms characterized by decreased food intake and
salivation, motor incoordination, looping, weaving etc. Deltamethrin treated
rats showed statistical significant decrease in body weight. There was
decreased locomotor and rearing frequency but increased duration of immobility.
The social interaction was decreased and large foot angle was seen in treated
rats. Delayed onset of reflexes was also observed.
Conclusion: The present study, thus, shows a great deal of
variability in the toxicity and motor coordination in deltamethrin exposed
rats. Deltamethrin treated rats exhibited significant deficits in motor
abilities, coordination, and overall activity, as measured by footprint
analysis and open field indicate that exposure to deltamethrin can have
long-lasting motor and cognitive consequences.
Author(s) Details:
Anil Kumar,
Department of Anatomy and Neurobiology, College of Medicine and Health Sciences, National University, Sohar, Al Tareef, P.O. Box: 391, Sultanate of Oman.
Please see the link here: https://stm.bookpi.org/ACPR-V8/article/view/13966
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