Investigation of Total Phenolic and Flavonoid contents of Lettuce Grown in Katsina State, Nigeria | Chapter 8 | Research Advances and Challenges in Agricultural Sciences Vol. 3

While it is clear that dietetic choices and habits are contributing to the health state of individuals, mounting evidence suggests that biomolecular contents of foods vary in line with the nutritional milieu. Even when it is hard to distinguish the causal factors of this variation, Lettuces remain a perfect example of complementary food of the first order given the wide array of their nutritional constituents and having provided countless essential nutrients to the paradigms of nutrition and medicine. Various concentrations of Flavonoids or Total polyphenols in lettuce contribute to preventive strategies of several health conditions.

The aim of this study is to investigate Total Polyphenol and Flavonoids content of lettuce grown in Katsina state, North-west Nigeria and their potential beneficial role in consumers’ health. Samples of Lettuces collected from different farms in six different Local Governments Areas (LGA) of Katsina State, North-west Nigeria and prepared in Dutsinma city, are analyzed using selected techniques, independent of variations in the sample matrix. The separation of each targeted compound in this study involves the use of well known and previously tested methods.

Total polyphenols and Flavonoids content are determined from quercetin and gallic acid standard curves.

Statistical analysis demonstrates the association between the antioxidant activity and amount of Total Phenolic or Flavonoids content with specifiable correlation coefficient.

Overall, this study makes clear that substituting synthetic antioxidants with natural identical compounds sourced from locally available Lettuces provides greater health and economic benefits, given that they are less toxic, easily affordable and more tolerated by consumers.

Author(s) Details:

Gnimintakpa Joseph,
Stellar Data and IT Consulting LLC, Data Science, Analytics Training Institute, Hyattsville, Maryland, USA.

Umar Sabiu,
Federal University Dutsinma, Katsina State, Nigeria.

Muhammad Sani,
Institute of Mathematical Research, University Putra, Serdan, Malaysia.

Please see the link here: https://stm.bookpi.org/RACAS-V3/article/view/13270

Beneficial Effects of Quercetin on Ischemia/Reperfusion-Induced Liver Injury in an Animal Model | Chapter 1 | Advanced Concepts in Medicine and Medical Research Vol. 7

 Upbringing: Ischemia/reperfusion (I/R)-persuaded liver injury, which can lead to means failure, is a important complication of hepatic section. I/R-induced liver injury is infuriate by oxidative and nitrogen stress. Although quercetin, a plant-derivative flavonoid, is a potent antioxidant, various studies focused on the belongings of quercetin on I/R-induced liver injury.Aim of Study: In this place study, the effects of quercetin were checked in an animal model of I/R-induced liver harm.Methods: F344 rats were divided into a negative control group and a group doctored with intraperitoneal presidency of quercetin (100 mg/kg). In both groups, the entry vein was ligated for 60 brief time period to induce ischemia. Ancestry was collected following in position or time 60 min of reperfusion. Antitoxin transaminase levels, tumor necrosis determinant (TNF)- α levels, and blood nitrotyrosine levels were calculated. Livers were removed for histological examination.Results and End: Serum transaminases, TNF-α, and nitrotyrosine levels were significantly lower in the quercetin-doctored group compared accompanying the levels in the negative control group. Liver damage was reduced in the quercetin-considered group compared accompanying the negative control group. These results suggest that quercetin may weaken the effects of I/R harm via antioxidative belongings that inhibit proinflammatory cytokine production.

Author(s) Details:

Toru Shizuma,
Department of Physiology, Tokai University School of Medicine, 143, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Please see the link here: https://stm.bookpi.org/ACMMR-V7/article/view/12662

Optimization Extraction Conditions of Some Flavonoids from Elsholtzia ciliata Leaves by Response Surface Method | Chapter 4 | Current Overview on Pharmaceutical Science Vol. 9

 In this study, the distillation conditions of various flavonoid compounds from Elsholtzia ciliata leaves were optimized for one response surface means (RSM). The experiment was arranged in accordance with the Box - Behnken design accompanying 15 experiments and was built established an optimized process for the ancestry of ethyl gallate (Y1), rutin (Y2), apigenin (Y3), and quercetin (Y4) with 3 determinants of extraction hotness (X1), extraction period (X2) and pressure (X3). The conditions for optimizing the ancestry process to obtain the best content of some flavonoid compounds were at 57O C, 54 notes of meeting, and 100 bar pressure. The experimental principles at the optimal limits of ethyl gallate, rutin, apigenin, and quercetin are 97.65 ± 0.32 mg/100g, 35.50 ± 0.25 mg/100g, 17.62 ± 0.15 mg/100g, and 27.66 ± 0.20 mg/100g, respectively.

Author(s) Details:

Truong Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Dam Thi Bich Hanh,
Department of Science and Technology, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Dak Lak province, 630000, Vietnam.

Trinh Ngoc Thao Vy,
Department of Medicine and Pharmacy, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Dak Lak province, 630000, Vietnam.

Van-Tinh Nguyen,
Applied Biomedical Research Institute, Buon Ma Thuot Medical University, 298 Ha Huy Tap Street, Buon Ma Thuot, Dak Lak, 630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.

Manh Hung Tran,
School of Medicine & Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City 550000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Please see the link here: https://stm.bookpi.org/COPS-V9/article/view/10169

Synthesis of Novel Virus-Like Mesoporous Silica-ZnO-Ag Nanoparticles and Quercetin Synergize with NIR Laser for Omicron Mutated Covid-19 Virus Infectious Diseases Treatment| Chapter 5 | Research Advances in Microbiology and Biotechnology Vol. 2

 This work shows that novel viruslike mesopore silicazinc group of chemical elements/Ag nanoparticles (SZnOAg) synthesized and professionally composed on NIR laser irradiation accompanying quercetin to improve the removal the mutated virus as a biomedical application. A singular type of silica nanoparticles with a selfinflating tubular surface has existed successfully combined using a novel singlemicelle epitaxial growth process. The characteristics of the nanoparticles can be brought into harmony with respect to their core width, tubular length, and external diameter. Due to their biomimetic presentation, they can rapidly transform living containers into virus-like pieces, this SZnOAg nanomaterial has specific elimination effect on bacteriophage and Covid-19. Using epitaxial development, we can construct bacterium-like structures that maybe used for biomedicine applications. These nanomaterials and NIR ray of light could prepare the way to a new range of antiviral materials, due to the lowefficiency basic uptake of current nanoparticles, their requests in the biomedical field are limited. Herein, it obviously shows that novel mesoporous silica nanoparticles can be easily shown superior cellular rude answer property.

Author(s) Details:

Fadi Ibrahim Ahmed,
Chemistry Department, Al-Shujaa bin Al-Aslam School, Kuwait.

Please see the link here: https://stm.bookpi.org/RAMB-V2/article/view/9222

Dasatinib and Quercetin: Short-term Simultaneous Administration Yields Senolytic Effect in Humans | Chapter 04 | Issues and Developments in Medicine and Medical Research Vol. 2

 Background: The higher the number of cell divisions, the more senescent cells. In human and animal beings, senescent cells are one of the most poisonous cells. When their number reaches a certain level, it causes a lot of ageing indicators to appear. During the division phase, the cell's generation reaches ultimate morphogenetic state, according to the citogenetic centriolar hypothesis of ageing. As a result, programmed cell death (apoptosis) must be triggered; otherwise, the cell would enter a senescent state if it does not kill itself.

Senescent cells are responsible for age-related diseases. Partially eliminating senescent cells should theoretically result in increased life capacity. On Ercc1 -/ mice, this idea was confirmed. Dasatinib and quercetin were given to Ercc1 -/ mice on a regular basis, extending their lifespan and postponing age-related signs and diseases. We decided to put dasatinib and quercetin together to see if they had a senolytic effect in humans.

The clinical trial was conducted on 64 male volunteers over the age of 36 for this objective. To put things in perspective, our volunteers were divided into four groups, each with 16 members. Within 5 days, the D+Q group was given 50 mg of dasatinib and 500 mg of quercetin orally.

Methods: The entire trial was supplemented with thorough medical screening and a stair ascending test in order to register and analyse changes caused by the medication components.

As a consequence, 50mg of dasatinib combined with 500 mg of quercetin had a clear senolytic effect, which was supported by improved stair ascending test results and a calmed state of systolic blood pressure. This dosage combination of these two drugs is almost certainly safe.

Author(S) Details

Tkemaladze Jaba
International Longevity Centre- 0131, King Demetre Tavdadebuli 81, Tbilisi, Georgia.

View Book:- https://stm.bookpi.org/IDMMR-V2/article/view/5433