Phage Therapy and Phage-Based Drug Development: A Comprehensive Review | Chapter 1 | Pharmaceutical Science: New Insights and Developments Vol. 7

 

Phage therapy, the use of bacteriophages to treat bacterial infections, has a history dating back to the early 20th century. It is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria. Antibiotic resistance is an escalating global health crisis, posing a severe threat to the control of microbial diseases.  This comprehensive review explores the historical context, the modern resurgence of phage therapy, and phage-facilitated advancements in medical and technological fields. It details the mechanisms of action and applications of phages in treating MDR bacterial infections, particularly those associated with biofilms and intracellular pathogens. The review further highlights innovative uses of phages in vaccine development, cancer therapy, and as gene delivery vectors. Despite its targeted and efficient approach, phage therapy faces challenges related to phage stability, immune response, and regulatory approval. By examining these areas in detail, this review underscores the immense potential and remaining hurdles in integrating phage-based therapies into modern medical practices.

 

Author(s) Details

Longzhu Cui
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Shinya Watanabe
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Kazuhiko Miyanaga
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Kotaro Kiga

Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan and Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.

 

Teppei Sasahara
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Yoshifumi Aiba
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Xin-Ee Tan
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Srivani Veeranarayanan
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Kanate Thitiananpakorn
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Huong Minh Nguyen
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.

 

Dhammika Leshan Wannigama
Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata 990-2292, Japan.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v7/4886

Synthesis of Novel Virus-Like Mesoporous Silica-ZnO-Ag Nanoparticles and Quercetin Synergize with NIR Laser for Omicron Mutated Covid-19 Virus Infectious Diseases Treatment| Chapter 5 | Research Advances in Microbiology and Biotechnology Vol. 2

 This work shows that novel viruslike mesopore silicazinc group of chemical elements/Ag nanoparticles (SZnOAg) synthesized and professionally composed on NIR laser irradiation accompanying quercetin to improve the removal the mutated virus as a biomedical application. A singular type of silica nanoparticles with a selfinflating tubular surface has existed successfully combined using a novel singlemicelle epitaxial growth process. The characteristics of the nanoparticles can be brought into harmony with respect to their core width, tubular length, and external diameter. Due to their biomimetic presentation, they can rapidly transform living containers into virus-like pieces, this SZnOAg nanomaterial has specific elimination effect on bacteriophage and Covid-19. Using epitaxial development, we can construct bacterium-like structures that maybe used for biomedicine applications. These nanomaterials and NIR ray of light could prepare the way to a new range of antiviral materials, due to the lowefficiency basic uptake of current nanoparticles, their requests in the biomedical field are limited. Herein, it obviously shows that novel mesoporous silica nanoparticles can be easily shown superior cellular rude answer property.

Author(s) Details:

Fadi Ibrahim Ahmed,
Chemistry Department, Al-Shujaa bin Al-Aslam School, Kuwait.

Please see the link here: https://stm.bookpi.org/RAMB-V2/article/view/9222