Beneficial Effects of Quercetin on Ischemia/Reperfusion-Induced Liver Injury in an Animal Model | Chapter 1 | Advanced Concepts in Medicine and Medical Research Vol. 7

 Upbringing: Ischemia/reperfusion (I/R)-persuaded liver injury, which can lead to means failure, is a important complication of hepatic section. I/R-induced liver injury is infuriate by oxidative and nitrogen stress. Although quercetin, a plant-derivative flavonoid, is a potent antioxidant, various studies focused on the belongings of quercetin on I/R-induced liver injury.Aim of Study: In this place study, the effects of quercetin were checked in an animal model of I/R-induced liver harm.Methods: F344 rats were divided into a negative control group and a group doctored with intraperitoneal presidency of quercetin (100 mg/kg). In both groups, the entry vein was ligated for 60 brief time period to induce ischemia. Ancestry was collected following in position or time 60 min of reperfusion. Antitoxin transaminase levels, tumor necrosis determinant (TNF)- α levels, and blood nitrotyrosine levels were calculated. Livers were removed for histological examination.Results and End: Serum transaminases, TNF-α, and nitrotyrosine levels were significantly lower in the quercetin-doctored group compared accompanying the levels in the negative control group. Liver damage was reduced in the quercetin-considered group compared accompanying the negative control group. These results suggest that quercetin may weaken the effects of I/R harm via antioxidative belongings that inhibit proinflammatory cytokine production.

Author(s) Details:

Toru Shizuma,
Department of Physiology, Tokai University School of Medicine, 143, Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Please see the link here: https://stm.bookpi.org/ACMMR-V7/article/view/12662

A Rare Complication of Propofol Infusion Syndrome: Diagnosis and Treatment | Chapter 8 | A Case in a Million

 This chapter reports about a rare complication of propofol infusion syndrome.  Propofol infusion syndrome (PRIS) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes. Propofol is a sedative-hypnotic medication commonly used as an induction agent for preoperative sedation, prior to endotracheal intubation and other procedures as well as for sedation in the intensive care unit. This may result in multi-organ system failure with potentially fatal consequences due to cellular damage. We report about a case of 46-year-old male with a past medical history of asthma and substance drug abuse. He was brought in by emergency medical services (EMS) when his sister found him unresponsive on the floor, having difficulty breathing. This patient was brought in due to unresponsiveness secondary to multi-substance abuse and respiratory disease and initially had elevated creatinine kinase levels that eventually subsided with appropriate management.  His creatinine kinase values, however, started to sharply increase with a protracted propofol infusion, suggesting the onset of propofol infusion syndrome. Creatinine kinase levels in the patient resumed to normal after the offending drug was stopped.

Author(s) Details:

Tutul Chowdhury,
One Brooklyn Health, Interfaith Medical Center, New York, USA.

Please see the link here: https://stm.bookpi.org/ACIM/article/view/12579