Showing posts with label lifespan. Show all posts
Showing posts with label lifespan. Show all posts

Monday, 14 July 2025

Optimizing Quarry Equipment Maintenance Through Reconditioning of Components Subject to Abrasive Wear | Chapter 1 | Engineering Research: Perspectives on Recent Advances Vol. 9

 

This study rigorously analyses the operational reliability and maintainability of critical metal components susceptible to abrasive wear within the technological equipment of the Pătârș basalt quarry. By integrating tribological wear parameter analysis with robust reliability and maintainability modelling, the research quantifies their direct impact on equipment efficiency and lifespan. We assessed components such as the Komatsu WA470 front loader bucket knife, Komatsu HB365 excavator bucket teeth, and the sorting station trough, alongside evaluating alternative materials like Hardox 400 steel and Pucest panels with perforated metallic inserts. Our methodology employed statistical distributions (lognormal and three-parameter Weibull) for reliability and maintainability, complemented by laboratory tribological tests on rock-metal pairs to quantify wear. Key findings reveal significant reliability degradation across all components with increased operating time, necessitating proactive maintenance. Notably, weld reconditioning proved highly effective, achieving a 68% increase in the operational lifespan of reconditioned bucket teeth. Furthermore, an economic analysis demonstrated that while alternative materials like Hardox 400 and Pucest have higher initial costs, their significantly extended operational lifespans (achieving 80% reliability for 157 and 251 days, respectively, compared to 105 days for the original material) promise substantial long-term cost-effectiveness through reduced replacement frequency and minimised downtime. This comprehensive study provides a robust framework for optimising quarry operations by strategically evaluating critical component reliability and implementing targeted maintenance interventions.

Author(s) Details

Mihaela TODERAȘ

Mining Engineering, Surveying and Civil Engineering Department, Faculty of Mines, University of Petrosani, 332006 Petrosani, Romania.

 Vlad Alexandru FLOREA|
Department of Mechanical, Industrial and Transportation Engineering, University of Petrosani, 332006 Petrosani, Romania.

 

Please see the book here:- https://doi.org/10.9734/bpi/erpra/v9/5788

Monday, 31 January 2022

Dasatinib and Quercetin: Short-term Simultaneous Administration Yields Senolytic Effect in Humans | Chapter 04 | Issues and Developments in Medicine and Medical Research Vol. 2

 Background: The higher the number of cell divisions, the more senescent cells. In human and animal beings, senescent cells are one of the most poisonous cells. When their number reaches a certain level, it causes a lot of ageing indicators to appear. During the division phase, the cell's generation reaches ultimate morphogenetic state, according to the citogenetic centriolar hypothesis of ageing. As a result, programmed cell death (apoptosis) must be triggered; otherwise, the cell would enter a senescent state if it does not kill itself.

Senescent cells are responsible for age-related diseases. Partially eliminating senescent cells should theoretically result in increased life capacity. On Ercc1 -/ mice, this idea was confirmed. Dasatinib and quercetin were given to Ercc1 -/ mice on a regular basis, extending their lifespan and postponing age-related signs and diseases. We decided to put dasatinib and quercetin together to see if they had a senolytic effect in humans.

The clinical trial was conducted on 64 male volunteers over the age of 36 for this objective. To put things in perspective, our volunteers were divided into four groups, each with 16 members. Within 5 days, the D+Q group was given 50 mg of dasatinib and 500 mg of quercetin orally.

Methods: The entire trial was supplemented with thorough medical screening and a stair ascending test in order to register and analyse changes caused by the medication components.

As a consequence, 50mg of dasatinib combined with 500 mg of quercetin had a clear senolytic effect, which was supported by improved stair ascending test results and a calmed state of systolic blood pressure. This dosage combination of these two drugs is almost certainly safe.

Author(S) Details

Tkemaladze Jaba
International Longevity Centre- 0131, King Demetre Tavdadebuli 81, Tbilisi, Georgia.

View Book:- https://stm.bookpi.org/IDMMR-V2/article/view/5433