Association between Candida in Oral Submucous Fibrosis and Oral Lichen Planus | Chapter 7 | Research Perspectives of Microbiology and Biotechnology Vol. 6

Candida species are component of oral micro flora with prevalence of 3-70%, and are generally regarded as being commensals, hence probable role of candida in oral carcinogenesis cannot be excluded. Various microbiological studies suggest association of candida with potentially malignant lesions. Pathogenicity of candida depends on many factors such as; nutritional disorders, diabetes mellitus, long-term antibiotic or corticosteroid use, head and neck cancer, radiation therapy and HIV infections.

 

Oral Submucous fibrosis (OSMF) is considered a as a high-risk precancerous condition that is associated with chewing areca nut. This is noticed that OSMF, patients show Candida colonization and further leading to malignant transformation. Similarly Oral Lichen Planus (OLP) is an autoimmune potentially malignant disorder. Recently researchers have noticed pathogenic microorganisms, such as Candida albicans in patients with oral lichen planus. Few studies have suggested that symptoms of Oral Lichen Planus may be exacerbated by candida overgrowth or infection. According to our findings; higher candida carriage revealed in OSMF+ OLP groups (23.3%); as compared to controls (10%). The species level findings showed 13.3% of candida albicans in OSMF+ OLP and6.7% in controls, candida krusei 6.7% in OSMF+ OLP and 3.3% in controls and non-candida albicans were 10% in OSMF+ OLP and 6.7% in control group respectively.

 

Conclusion: The association of candida species with potentially malignant disorders such as OSMF and OLP aggravate to malignancies through secondary infections. So early assessment of these microbes in preliminary state of cancers can avoid further complications and help for better interventions.

 

 

Author (s) Details.

Ashok Vikey
Department of Oral and Maxillofacial Pathology, Govt. College of Dentistry, MPMSU, Indore, M.P., India.

 

Astha Pusame
Department of Oral and Maxillofacial Pathology, Govt. College of Dentistry, MPMSU, Indore, M.P., India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rpmab/v6/1477

 

Insights into Oral Lesions Epidemiology and Risk Factors in North India: Findings from a Comprehensive Hospital-Based Investigation | Chapter 3 | New Visions in Medicine and Medical Science Vol. 3

 Aim: The present study was conducted to understand the clinical profile of individuals with oral precancerous lesions or oral cancer, estimate the relative prevalence of these disorders, and test the hypothesis that chewing tobacco/pan masala is a risk factor for them.

 

Background:  One of the most prevalent and deadly illnesses is oral cancer throughout the world. There are various obstacles that developing nations must overcome in order to locate and eliminate possible danger factors. Oral cancer and precancerous lesions are thought to be most strongly associated with tobacco chewing/pan masala.

 

Methodology: A hospital-based study was conducted and 471 subjects were recruited in the study. The subjects comprised patients with squamous cell carcinoma (n = 85), oral submucous fibrosis (n = 240), leukoplakia (n = 32), lichen planus (n = 15), and controls (n = 99). Statistical analysis of the data was done using Chi-square and regression analysis.

 

Results: A strong correlation was observed between the presence of the chewing habit in all the oral precancerous lesions and oral cancer. Duration of the habit and intensity of habit were also strongly correlated with the risk of oral precancerous lesions and oral cancer. Other factors such as alcohol and smoking were found to be less important in concern with oral cancer and precancerous lesions.

 

Conclusion: The Indian subcontinent bears one-third of the global burden. Annually, about 800,000 deaths in India result directly from tobacco-related cancers. Cancers of the oral cavity hold a critical position in healthcare systems due to the potential for early detection, which is both theoretically feasible and highly beneficial in practice. Early detection typically correlates with a significant reduction in the risk of disfigurement, recurrence, and mortality.

Author(s) Details:

Sharon John,
Department of Oral Pathology and Microbiology, King Georges Medical University, India.

Priya Devi,
Department of Oral Pathology and Microbiology, King Georges Medical University, India.

Shalini Gupta,
Department of Oral Pathology and Microbiology, King Georges Medical University, India.

Please see the link here: https://stm.bookpi.org/NVMMS-V3/article/view/13950

Oral Submucous Fibrosis – An Ayurvedic Perspective | Chapter 7 | New Advances in Medicine and Medical Science Vol. 6

 Oral Submucus Fibrosis (OSMF) is a pre-diseased condition for approximately 2% of the cases, leading to a meaningful deterioration in the Quality of Life, and food. The symptoms of OSMF include pain, blazing sensation, intolerance to pungent food, taste disorders, dry mouth, discounted opening of backtalk, dysphagia, altered tone and depreciated mobility of the tongue. Ayurveda refers to any similar illnesses as Tridoshaj Mukhapaka and advises several remedy modalities, including local cures such as Gandusha and systemic one such as consumption of Rasayana, Tridoshaghna herbs and herbals, in addition to Nidana Parivarjana / abstinence from addictions. This affiliate discusses many areas of OSMF as scholarly and clinical studies relevant to OSMF / Tridoshaj Mukhapaka in up-to-date medicine, such as stop, surgery, diet, behavior, physiotherapy, Ayurveda, and other Complementary Alternative Medicines.  Ayurvedic preventive & health-giving protocols are detailed present.

Author(s) Details:

Aparna Sharma,
Department of Shalakya Tantra, National Institute of Ayurveda Deemed to Be University, Jaipur 302002, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V6/article/view/10988

A Case Report on Management of Oral Submucous Fibrosis with Intralesional Injection of Hyaluronidase and Dexamethasone | Chapter 18 | Recent Developments in Medicine and Medical Research Vol. 4

 Oral submucous fibrosis (OSMF) is a persistent premalignant illness that is more frequent. Chewing betel quid is the most common reason. OSMF is distinguished by the gradual hyalinization of the submucosa. Its resistance and progression are aided by the fact that it affects the whole mucosa. It causes a slow narrowing of the mouth, which may spread to the pharynx. Connective tissue fibrosis is caused by this potentially cancerous disease. Despite the fact that medical treatment is mainly symptomatic, appropriate doses of corticosteroids, hyaluronidase, and local anaesthetic injections reduced clinical symptoms significantly. The goal of this study is to investigate the use of medicinal therapy as an adjuvant in reducing the stage of OSMF, hence reducing the need for surgical management or improving surgical management success. We present a case of OSMF that was treated in a similar way and produced better results than either agent alone. The most important result of the treatment was an increase in mouth opening with a decrease in burning sensation.

Author(S) Details

Thamizhp Pozhil Guna
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

R. Sathyanarayanan
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

S. Bharathi
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

C. Selvakumar
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

K. Madhu
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

Raja Sethupathy Cheemaan
Department of Oral and Maxillofacial Surgery, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pillayarkupam, Puducherry, India.

View Book:- https://stm.bookpi.org/RDMMR-V4/article/view/4183