Ipomoea biloba (Convolvulaceae) is a water-loving creeping
plant and is esteemed in traditional medicine for its different types of
therapeutic applications in various diseases like asthma, rheumatism, and
burns. Despite it has been used historical use, a comprehensive scientific
validation of its bioactivity is essential. This chapter explores the detailed
systematic investigation of the phytochemical constituents and pharmacological
activity of the potential of a methanol extract of Ipomoea biloba leaves (MEIB).
The Methanol was used as an extraction solvent to accomplish a wide different
ranging recovery of phytoconstituents because of its well-balanced polarity.
The preliminary phytochemical profiling of MEIB confirmed the presence of a
variety of secondary metabolites, including alkaloids, flavonoids, phenols,
terpenoids, saponins, steroids, carbohydrates, and amino acids. The in vitro
antioxidant capacity of MEIB was assessed using standard assays, revealing
significant, dose-dependent free radical scavenging activity comparable to
ascorbic acid, thereby underscoring its potential to ameliorate oxidative
stress. Furthermore, the cytotoxic efficacy of MEIB was assessed against the
human breast adenocarcinoma (MCF-7) cell line. The extract demonstrated a potent
and dose-dependent inhibition of cell proliferation, suggesting notable
anticancer properties. This cytotoxic activity may be mechanistically linked to
the presence of phytoestrogenic compounds, like estradiol precursors, known to
interact with estrogen receptors in the cytoplasm of target cells. The
collective study findings from this robust position Ipomoea biloba as a
promising reservoir of bioactive compounds. The findings not only validate its
ethnomedicinal uses but also highlight its significant potential as a source
for the development of natural antioxidant and anticancer agents. Further
research is needed to isolate, characterise, and confirm the specific molecules
responsible for these observed biological activities.
Author(s) Details
Geetha Rani Kumar
Department of Biochemistry, Muthayammal College of Arts and Science (A),
Rasipuram, Namakkal, India.
Shobana Devi Paulraj
Department of Biochemistry, Shrimati Indira Gandhi College,
Thiruchirapalli, India.
Vallipriya Rajendran
Department of Biochemistry & Biotechnology, Pavendar Bharathidasan
College of Arts and Science (PBCAS), (Bharathidasan University)
Thiruchirapalli, India.
Kiruthika Natarajan
School of Allied Health Science, Vinayaka Missions Research Foundation,
Deemed to be University, Salem, India.
Please see the book here :- https://doi.org/10.9734/bpi/cmsrf/v6/6704
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