Introduction: Pentraxin 3 (PTX3) is an acute-phase protein
that stands at the intersection between inflammation and cardiovascular
pathology. Influential role of PTX3 impacts vascular inflammation, endothelial
function and atherosclerotic progression. Pentraxin vascular health is staged
by its dual role as a biochemical marker and a potential modulator that
provides greater specificity than systemic C-reactive protein. Data synthesised
positions pentraxin as a promising candidate for precision cardiovascular
medicine. PTX3 is a long pentraxin
produced by stromal and myeloid cells in response to inflammatory signals and
microbial moieties. It plays a multifunctional role in inflammation, acting as
a functional ancestor of antibodies.
Objective: This review explores the relationship between
PTX3 and cardiovascular risk, its diagnostic and prognostic value, and its
implications for clinical practice. The objectives focused on in this chapter
are the functional role of PTX3 to stratify patients according to the severity
of cardiovascular risk. Secondly, the prognostic role of elevated PTX3 levels
speaks about the worst outcome in patients with cardiovascular disease.
Thirdly, PTX3 can be considered as a therapeutic target that reinforces new
avenues of treatment.
Methodology: This book chapter is an outcome of a
comprehensive literature review that focused on articles from the PubMed
database, Scopus and Web of Science databases. Utilised the keywords such as
pentraxin 3, cardiovascular disease, atherosclerosis, and inflammation. Through
a reductionist approach, mechanistic insights with regard to the association
between pentraxin and cardiovascular health were framed.
Conclusion: PTX3 is a promising biomarker for cardiovascular
risk assessment and disease progression. Further research is needed to
establish standardised reference values and explore its potential as a
therapeutic target.
Author(s) Details
K. A. Arul Senghor
SRM Medical College Hospital & Research Centre, India.
V. M. Vinodhini
SRM Medical College Hospital & Research Centre, India.
Renuka. P
SRM Medical College Hospital & Research Centre, India.
M S. Vyshnavi
SRM Medical College Hospital & Research Centre, India.
Please see the book here :- https://doi.org/10.9734/bpi/msup/v3/6784
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