From Linkage to Neuronal Networks: An Updated Overview of Molecular Genetic Approaches in Schizophrenia Research| Chapter 4 | Microbiology and Biotechnology Research: An Overview Vol. 6

 

Schizophrenia (SCZ) is a highly complex biological disorder characterised by a multifactorial mode of transmission, where both genetic and non-genetic determinants play significant roles. Current evidence suggests that SCZ arises from the cumulative impact of numerous genes, each contributing a modest increase in susceptibility to the illness. This review provides an updated perspective on the genetics and genomics of SCZ, tracing the field from the pre-recombinant era through the genomics revolution. It encompasses key approaches such as cytogenetics, linkage studies, and genome-wide association studies (GWAS). Genomic analyses that have illuminated gene signatures include microarray profiling, RNA methylation studies, and single-cell analyses. In addition, diverse animal and cellular models are discussed, highlighting their applications in unravelling SCZ pathology. Systems biology and neuronal network analyses have offered critical insights into the intricate phenotypes associated with the disorder. Emerging technologies, including 3D chromatin architecture studies and optogenetics, are further advancing the field by enabling deeper exploration of neuronal function and regulation. The review, through its efforts, is proposed to highlight major findings in SCZ genetics. The scientific advances are essential in the individual genomes to detect and diagnose SCZ with newer perspectives and advances and tailor therapeutic interventions.

 

Author(s) Details

Ranjini P
Department of Biotechnology, Sir MV Government Science college Bhadravathi, Karnataka, India.

 

Shreya K R
Department of Plant Biotechnology, University of Agricultural Sciences, India.

 

Priya MD
Department of Zoology, Government Science College, Nrupathunga University, Nrupathunga Road, Bangalore, 560001, India.

 

Kamatchi C
Department of Biotechnology, The Oxford College of Sciences, Bangalore, India.

 

Tenkanidiyooru Ramamoorthy Prashith Kekuda
Department of Microbiology, S.R.N.M College of Applied Science. N.E.S Campus, Balraj Urs Road, Shimoga-577201, India.

 

Kiran Kumar H.B
Former-PDF NCBS, Resource person Nrupathunga University, Bangalore, India.

 

Please see the link:- https://doi.org/10.9734/bpi/mbrao/v6/6764