Novel drug delivery systems have made great progress in the
field of nanotechnology. This review focuses on different aspects of
proniosomes such as preparation, characterization, in vitro drug release,
entrapment efficiency, applications in the present scenario in the market and
future trends. In the development of new dosage forms, drug delivery using
nanotechnology is playing a vital role. Vesicular drug delivery systems have
gained wide attention in the field of nanotechnology, such as niosomes, liposomes
and proniosomes. Among the vesicular carriers, proniosomes are superior.
Proniosomes are water-soluble carrier particles that are coated with surfactant
so these are dry formulations. They are rehydrated to use on agitation in hot
aqueous media within minutes to form niosomal dispersion immediately. Both
hydrophilic and lipophilic drugs can be incorporated into these proteasomes.
The physical stability problems of niosomes like aggregation, fusion and
leaking are minimized in proniosomes, routes, such as oral, parenteral, dermal
and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. In
the treatment of hypertension, Proniosomes are used as carriers for the
transdermal delivery of captopril. Proniosomes are also used for the delivery of
levonorgestrel the emergency contraceptive and many more. Proniosomes prolong
the existence of the drug in the systemic circulation and finally reduce
toxicity. Proniosomes are an effective
tool for targeting of drugs and have the potential to provide better treatment
than conventional drug delivery system.
Author(s) Details:
Saritha Medapati
Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India.
Satya Prakash Panda
Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India.
Krishna Mannem
Sir, C R Reddy College of Pharmaceutical Sciences, Eluru, India.
Latha Kukati
G. Pulla Reddy College of Pharmacy, Hyderabad, India.
Please see the book here:
https://doi.org/10.9734/bpi/prrat/v1/8352E
No comments:
Post a Comment