Background: Pain
is a distressing feeling to an intense or damaging stimulus. For centuries,
natural analgesic compounds have been used to mediate the pain process, and
often with fewer side effects. Moringa oleifera is highly valued with a wide
range of medicinal uses. It is abundantly available in tropical and
sub-tropical countries. It has been used as an analgesic and anti-inflammatory
in Indian folk medicine for centuries. The mechanism of action of analgesic
effect is by the phytochemical components of its leaves which contain
alkaloids, glycosides, phenols, saponins and tannin.
Methods:
Twenty-four Albino mice of either sex, weighing 20-30 grams were selected for
the experiment, and divided into 4 equal groups. This experiment was carried
out in the mice by using the thermal method of analgesiometer which is Eddy’s
Hot Plate method. A thermostatically controlled electrically heated plate was
used in this method. Ethanolic and aqueous extracts of Moringa oleifera leaf
extracts were compared with aspirin. To the mice of the control group,
distilled water was given, for the standard group mice aspirin at the dose of
35 mg/kg was given. For the test groups, aqueous and ethanolic extracts were
given at 100 mg/kg dose.
Results: When the
analgesic properties of the standard drug aspirin were compared to the
analgesic properties of ethanolic and aqueous extracts of Moringa oleifera, the
ethanolic extract showed a comparable analgesic effect with aspirin at 90 min.
Among these two extracts, the ethanolic extract showed a higher response than
the aqueous extract.
Conclusions: When
the analgesic properties of the standard drug aspirin were compared to the
analgesic properties of ethanolic and aqueous extracts of Moringa oleifera, the
ethanolic extract showed a comparable analgesic effect with aspirin at 90 min.
Among these two extracts, the ethanolic extract showed a higher response than
the aqueous extract. The plant has to be further explored for its phytochemical
profile to identify the active.
Author(s) Details:
Prashanth Kumar
Patnaik
Department of Pharmacology, Mahavir Institute of Medical Sciences,
Vikarabad, Telangana, India.
Mohammed Abdul Majeed
Markapuram Medical College, Andhra Pradesh-523316, India.
Bhuvaneshwari
Department of Pharmacology, Osmania Medical College, Hyderabad, Telangana,
India.
Laksmi Kameswari
Department of Pharmacology, RIMS, Nizamabad, Telangana, India.
M. B. Niharika
Department of Pharmacology, Mahavir Institute of Medical Sciences,
Vikarabad, Telangana, India.
Please see the book here:
https://doi.org/10.9734/bpi/prrat/v1/2965G
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