Conventional taste masking methods including the use of
sweeteners, amino acids and flavoring agents are often inadequate in masking
the taste of highly bitter substances such as NSAIDs, i.e. ibuprofen,
diclofenac sodium, mefenamic acid and etc., especially when these drugs are
administered via the orally as syrups or solutions. The X-ray crystal structure
of the enzyme COX-2 and the chemical structures of widely used non-steroidal
anti-inflammatory drugs (NSAIDs) that bind to COX enzymes and activate the bitter
taste receptor TAS2R14 are used in this commentary to discuss a novel approach
to be used in the design of active sites of bitter taste receptors, especially
TAS2R14. In order to better understand the nature of the interactions between
bitter tastants and the chemical groups within the active site of the TAS2R14
receptor, the suggested approach entails docking calculations of the NSAIDs
(ligands) to the active site of COX-2.
Author(s) Details:
Rafik Karaman
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Quds
University, Jerusalem, Palestine and Department of Sciences, University of
Basilicata, Viadell’Ateneo Lucano 10, 85100, Potenza, Italy.
Gennaro Mecca
Ricercatore at EXO
Ricerca, Potenza, Italy.
Salma Jumaa
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Quds
University, Jerusalem, Palestine.
Please see the book here:
https://doi.org/10.9734/bpi/prrat/v1/68
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