A Sustained-Release Drug Delivery System is specially
designed to provide a drug in the human body at a predetermined and constant
rate (zero order dissolution). The
primary objective of sustained-release drug delivery is to ensure safety and to
improve the efficacy of drugs as well as patient compliance. Conventional
dosage forms are accused of repetitive dosing and unpredictable absorption
windows that cause a wide range of fluctuations in drug concentration in the
bloodstream and tissues with subsequent undesirable toxicity and poor
therapeutic efficiency. Bi-layer tablet is suitable for the sequential release
of two drugs in combination, separating two incompatible substances and also
for sustained release tablets in which one layer is immediate release as the
initial dose and the second layer is the maintenance dose. The goal of the
present investigation was to formulate and evaluate bilayered tablets of
Candisartan Cilexetil for an extended period of time. The tablets were prepared
by using different polymers (Sodium Alginate, Ethyl Cellulose, HPMC K100M) in
various proportions by using (Direct compression method technique). The tablets were evaluated for Angle of
Repose, Bulk Density, Taped Density, Weight Variation, Thickness, Hardness,
Friability, Determination of drug content, Scanning Fourier transform- infrared
spectroscopic analysis (FT- IR), In vitro Disintegration time Studies, In-vitro
drug release studies, Stability studies of tablets and ex-vivo residence time.
Nine formulations were developed by using different polymers in different
proportion. The formulation F7 shows an in vitrodrug release of 96.28% in 12 h
along with satisfactory results. From the experimental results, it was
concluded that F7 was the best formulation based on dissolution profile and
physical characteristics. Formulation (F7) showed total drug release in 12
hours and showed fair flow properties when compared to other formulations.
Author(s) Details:
Raja Narender. B
Sree Chaitanya Institute of Pharmaceutical Sciences, Thimmapoor,
Karimnagar, Telangana 505527, India.
P. Pavan Kalyan
Sree Chaitanya Institute of Pharmaceutical Sciences, Thimmapoor,
Karimnagar, Telangana 505527, India.
Please see the book here:
https://doi.org/10.9734/bpi/prrat/v1/8518E
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