The objective of the study was to synthesize and
characterize the N-substituted tetrahydrocarbazole compounds, along with
molecular docking studies of the synthesized compounds associated with the
evaluation of anti-bacterial activity by the agar cup method. Drug design,
often referred to as rational drug design or simply rational design, is the
inventive process of finding new medications based on the knowledge of a
biological target. The heterocyclic compounds named tetrahydrocarbazoles have
significant biological properties. The recently created substituted
tetrahydrocarbazole compounds were made by refluxing substituted cyclohexanone
and phenylhydrazine in glacial acetic acid. These intermediates were ultimately
transformed into N-substituted tetrahydrocarbazoles through a reaction with
substituted aromatic acid chlorides in alkaline conditions. Fifteen compounds are synthesized and
characterized by their melting point (MP), IR, NMR, MS, and elemental analysis.
All the compounds were subjected to molecular docking studies for Gln-6-p
enzyme (1XFF) inhibition. The newly synthesized tetrahydrocarbazole derivatives
were studied for anti-microbial activity using the agar cup method. In silico
studies revealed that all the synthesized compounds have relatively better
binding affinity as compared to the standard drug. So, it may be considered a
good inhibitor of GlcN-6-P. The
anti-microbial activity was assessed by the agar cup plate method, and the
results showed eight compounds having a better anti-microbial response against
the bacterial and fungal strains. The study helps to expand the scope of
developing these tetrahydrocarbazole derivatives, which help to promote
effective anti-bacterial agents.
Author(s) Details:
Sakinala Padmavathi
Department of Pharmaceutical Chemistry & Phytochemistry, Nirmala
College of Pharmacy, Atmakur, Mangalagiri, Guntur-522503, India
Ramu Bhadramaraju
Department of Pharmaceutical Sciences, Madhira Institute of Science and
Technology (Mits College of Pharmacy), Palennaram, Chilkure, Kodad, Suryapet
District, Telangana, India.
Mamatha Uddoju
Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur,
Maharashtra, 440033, India.
Nosina Venkataramana
Department of Pharmaceutical Chemistry & Phytochemistry, Nirmala
College of Pharmacy, Atmakur, Mangalagiri, Guntur-522503, India.
Madhukar Rajaram
Tajne
Department of Pharmaceutical Chemistry & Phytochemistry, Nirmala
College of Pharmacy, Atmakur, Mangalagiri, Guntur-522503, India.
Illuri Supriya
Department of Pharmaceutical Chemistry & Phytochemistry, Nirmala
College of Pharmacy, Atmakur, Mangalagiri, Guntur-522503, India.
Please see the book here:
https://doi.org/10.9734/bpi/prrat/v1/41
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