Innovations in Vesicular Drug Delivery: The Proniosomal Approach for Enhanced Therapeutic Efficacy | Chapter 2 | Pharmaceutical Research - Recent Advances and Trends Vol. 1

 

Novel drug delivery systems have made great progress in the field of nanotechnology. This review focuses on different aspects of proniosomes such as preparation, characterization, in vitro drug release, entrapment efficiency, applications in the present scenario in the market and future trends. In the development of new dosage forms, drug delivery using nanotechnology is playing a vital role. Vesicular drug delivery systems have gained wide attention in the field of nanotechnology, such as niosomes, liposomes and proniosomes. Among the vesicular carriers, proniosomes are superior. Proniosomes are water-soluble carrier particles that are coated with surfactant so these are dry formulations. They are rehydrated to use on agitation in hot aqueous media within minutes to form niosomal dispersion immediately. Both hydrophilic and lipophilic drugs can be incorporated into these proteasomes. The physical stability problems of niosomes like aggregation, fusion and leaking are minimized in proniosomes, routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. In the treatment of hypertension, Proniosomes are used as carriers for the transdermal delivery of captopril. Proniosomes are also used for the delivery of levonorgestrel the emergency contraceptive and many more. Proniosomes prolong the existence of the drug in the systemic circulation and finally reduce toxicity.  Proniosomes are an effective tool for targeting of drugs and have the potential to provide better treatment than conventional drug delivery system.

 

Author(s) Details:

 

Saritha Medapati
Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India.

 

Satya Prakash Panda
Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India.

 

Krishna Mannem
Sir, C R Reddy College of Pharmaceutical Sciences, Eluru, India.

 

Latha Kukati
G. Pulla Reddy College of Pharmacy, Hyderabad, India.

 

Please see the book here:  https://doi.org/10.9734/bpi/prrat/v1/8352E

Study of Langmuir-Blodgett Films of Synthetic Artificial Mimic Molecules Resembling the Following Tetraether Lipids on Silicon Wafers | Chapter 2 | Current Topics on Chemistry and Biochemistry Vol. 9

 The study examined the nature and microscopic organization of artificial artificial mimic fragments resembling the following tetraether lipids: di-O-hexadecyl-glycero-3-phosphatidyl-glycerol (DHGPG) and another time-4-dodecylphenyl-12- phosphate. These molecules were resolved using associations of Langmuir film balance, ellipsometry and tiny force microscopy. Langmuir-Blodgett monolayer film from DHGPG and bis-4-dodecylphenyl-12-phosphate resistant on modification hard surface silicon wafers (hydrophilic, hydrophobic and Amino-silanized). The ellipsometry and AFM results showed that the Langmuir-Blodgett monolayer films of DHGPG and another time-4-dodecylphenyl-12-phosphate were present, and the observed film girth  varied from 1.2 - 5.0 nm.The qualification of the solid surface-backed wafer silillon to hydrophilic, hydrophobic, Amino-silanized is very main and causes Langmuir Blodgett monolayer films of DHGPG and bis-4-dodecylphenyl-12-phosphate to enhance stable on a dimensional surface wafer silicon. If outside surface modification of silicon disk to hydrophilic or hydrophobic or Amino-silanized, Langmuir Blodgett monolayer film of DHGPG and repeated-4-dodecylphenyl-12-phosphate have unstable.

Author(s) Details:

Sri Vidawati,
Sri Vidawati, Faculty of Post Graduate, National Institute of Science and Technology, Jakarta, Indonesia.

Ulrich Rothe,
Institute of Physiological Chemistry, Faculty of Medicine, University Halle-Wittenberg, Hollystr, Halle/Saale, Germany.

Please see the link here: https://stm.bookpi.org/CTCB-V9/article/view/9753

Lipid-Polymer Hybrid Nanocarriers as a Promising Nanocarrier for Drug Delivery| Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol. 9

 Objective: The basic goal concerning this review is to discuss ultimate prominent nanocarrier “Lipid-Polymer Hybrid Nanoparticle” (LPHNP) that overcomes the disadvantage of lipid and polymeric nanoparticles.  This is made up of a polymeric gist and lipid as an outer coating. Lipid-based Nanoparticle has some disadvantages like insufficient drug stowing, fast drug release and physical and synthetic instability all along storage. The polymeric core epitomizes both hydrophilic & hydrophobic drugs and the lipid covering is also gifted to encapsulate lipophilic drugs and provides a coat that gives a obstacle to prevent drug discharge & easily intelligent to the skin. The LPHNPs have a wide range of requests in drug delivery, drug targeting, tumor treatment, intelligence drug delivery, diversified drug delivery, delivery of demonstrative imaging powers and Small interfering Ribonucleic acid (siRNA) etc.Methods: This gathering is based on material from the information, where two-step and Single-step designs were used to manufacture LPHNPs. Most analysts employ the Single-step order of nanoprecipitation and single-step stable evaporation for creating LPHNPs.  Polylactic Glycolic acid (PLGA), Poly € caprolactone, Chitosan, Alginate, Dextron, Sodium Alginate, etc are secondhand as polymeric core and Stearic Acid, Palmitic Acid, Cetyl Alcohol, Behenol Alcohol, etc secondhand as lipid core.Results: We judged each finding in light of the research and the writers' knowledge. Diffusion mechanisms, attended by erosive processes and origin swelling, are all necessary for drug release. The lipid structure offers a biocompatible barrier that functions like the skin's phospholipid bilayer and is quickly absorbed for one skin. For the treatment of cancer, that is to say also intelligent to deliver multi-drug and demonstrative imaging powers.Conclusion: The Lipid-Polymer Hybrid Nanoparticles are the most well-known nanocarrier for drug childbirth.  It has a high bioavailability and is worthy delivering two together hydrophilic and lipophilic medications.

Author(s) Details:

Pankaj Kumar Jaiswal,
IEC College of Engineering & Technology, Greater Noida, Uttar Pradesh-201310, India.

Princy Malik,
IEC College of Engineering & Technology, Greater Noida, Uttar Pradesh-201310, India.

Shikha Kesharwani,
Chandra Shekhar Singh College of Pharmacy, Prayagraj, Uttar Pradesh-212203, India.

Priyanka Singh,
IEC College of Engineering & Technology, Greater Noida, Uttar Pradesh-201310, India and Department of Pharmacy, Banasthali Vidyapith, Tonk, Rajasthan-304022, India.

Sakshi Gupta,
ABESIT College of Pharmacy, Uttar Pradesh-201009, India.

Please see the link here: https://stm.bookpi.org/CAPR-V9/article/view/8674