Antibiotic lock solutions is recommended as an adjunctive therapy for patients who have catheter
related bloodstream infections. The aims of our study
is, to determine the in-vitro efficacy of
colistin,
ciprofloxacin, tobramycin, and doripenem alone or in
combination with clarithromycin as 24 hour lock
solutions against biofilm-embedded Enterobacterales
(Escherichia coli and Enterobacter
cloacae)
strains. The efficacy of antibiotic lock solutions was
tested in an in-vitro catheter biofilm model against
two E. coli and two E. cloacae isolated from
catheter tip, respectively. In our study, we observed that
the use of doripenem and tobramycin as a lock solution
had potent bactericidal effects (> 3 log10
reduction).
When colistin was used in combination with clarithromycin, the combination
showed
synergistic activity for one E. cloacae strain.
Tobramycin, doripenem, and ciprofloxacin were used in
combination with clarithromycin, the combinations had
same effect on all strains comparatively with
these antibiotics alone. No antagonistic effect was
observed. The findings of our study have important
informations for effectiveness of tested antibiotic
lock solution with these antibiotics alone or in
combination in the catheter related infections with
belonging to Enterobacterales. Further
investigations are needed to alternative treatment
options for catheter related infections that were
caused by Enterobacterales
Author(s) Details
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Beyazit, Istanbul, Turkey.
Berna Özbek Çelik
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Beyazit, Istanbul, Turkey.
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