Role of Honey as a Nutraceutical: A Review | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 7

Honey has been revered not only as a natural sweetener but also for its numerous health benefits. This chapter delves into honey as a nutraceutical, exploring its multifaceted role in promoting health and preventing disease. Nutraceuticals, defined as products derived from food sources with extra health benefits in addition to their basic nutritional value, have gained significant attention in recent years. Honey stands out due to its rich composition of bioactive compounds, including flavonoids, phenolic acids, vitamins, minerals, and enzymes. The therapeutic properties of honey are attributed to its antioxidant, anti-inflammatory, antimicrobial, and wound-healing capabilities. This chapter provides a comprehensive review of scientific studies that highlight the efficacy of honey in various medical applications, such as treating infections, enhancing immune function, and managing chronic diseases like diabetes and cardiovascular disorders. Additionally, the study discuss the mechanisms through which honey exerts its beneficial effects, emphasizing its role in modulating oxidative stress and inflammatory pathways. In conclusion, honey, with its profound nutraceutical properties, offers a natural and holistic approach to health and wellness. This chapter aims to provide valuable insights for researchers, healthcare professionals, and consumers interested in the therapeutic potential of honey and its applications in modern medicine.

 

Author (s) Details

 

Miftakhul Cahyati
Department of Oral Medicine, Faculty of Dentistry, Brawijaya University, Malang-65145, Indonesia.

 

Agus Susilo
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

Khothibul Umam Al Awwaly
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

Firman Jaya
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

 

Premy Puspitawati Rahayu
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

 

Herly Evanuarini
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

 

Dedes Amertaningtyas
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

 

Ria Dewi Andriani
Department of Animal Science, Faculty of Animal Science, Brawijaya University, Malang-65145, Indonesia.

 

Dodyk Pranowo
Department of Agroindustrial Technology, Faculty of Agricultural Technology, Brawijaya University,
Malang-65145, Indonesia.

 

Nurjannah
Department of Statistics, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia.

 

Asep Awaludin Prihanto
Department of Fishery Product Technology, Faculty of Fisheries and Marine Sciences, Brawijaya University, Malang-65145, Indonesia.

Dewi Masyithoh
Department of Animal Husbandry, Faculty of Animal Science, Islamic University of Malang, Malang-65145, Indonesia.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v7/2271

Integrated Neurorehabilitation (INRA) for Children with Cerebral Palsy: Protocol and Case Report on Promoting Neuroplasticity | Chapter 5 | Achievements and Challenges of Medicine and Medical Science Vol. 2

Cerebral palsy (CP) is the commonest cause of physical disability in children, but optimal rehabilitative protocols have yet to be determined, and progress in developing novel interventions has been slow. Neuroplasticity is no longer thought to be fixed in childhood, but instead develops throughout life; however, the best way to exploit the remodeling brain has yet to be determined. The management of CP must, therefore, be multidisciplinary to achieve the best outcomes. The use of nutraceuticals (a food or product with health benefits, or a dietary supplement) in the management of cerebral palsy is less well documented, but there are a few examples of studies examining the use of vitamin supplementation in children with CP,18,19 and children with CP are known to suffer from micronutrient deficiencies and anti-oxidant imbalances. This study presents a novel multimodal integrative medicine protocol for the management of children and adolescents with CP termed Integrated Neurorehabilitation (INRA). The basic INRA protocol combines physical therapy, magnetostimulation, and a nutraceutical regimen to provide endogenous and exogenous neurorestorative stimuli to damaged corticospinal pathways on a background of an optimized neuronal microenvironment. A 13-year-old boy with cerebral palsy was referred to the clinic with severe motor, intellectual, and speech deficits.  This study illustrates the protocol with the case of a 13-year-old boy showing marked improvements in gross motor function (GMFM-88 score 82% from 59%), speech (TOM score 3 from 0), and cognition (TOEM score 3 from 1) after four years of therapy. There was also a slight increase in his IQ and a decrease in epileptiform activity on EEG. Epileptiform activity on EEG was reduced. This study describe the protocol in full and the scientific rationale for its implementation. IRNA can be used alongside existing medical and rehabilitative regimens to promote neuroplasticity and synaptogenesis. Further testing of the protocol is required in a prospective clinical trial.

 

Author (s) Details

 

Maja Roje Novak
Neurologija-dr.Maja Roje Novak d.o.o., Private Clinic, Pavla Hatza 27, 10000 Zagreb, Croatia.

 

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v2/2685

Nutraceutical Benefits of Sesame Seeds and Oil: An Appraisal of Their Lignan Content and Health Implications | Chapter 7 | Contemporary Research and Perspectives in Biological Science Vol. 8

Sesame seed (Sesamum indicum L.) is a rich source of edible oil and lignans with a wide range of potential biological activities. The major lignans in sesame seeds are the oil-soluble sesamin and sesamolin, as well as glucosides of sesaminol and sesamolinol that reside in the defatted sesame flour. These properties have been proven to be very useful to humans when consumed. The information in this paper is very vital to those in the field of nutrition who are working on the job to handle the linkage between food and the well-being of humans. Subsequently, the eating of sesame seed products is growing steadily in many countries in the world, it is imperative to know about the contribution of lignans and sesame oil in food. Sesame seed is widely used in food and nutraceutical industries in many countries because of its high oil, protein and antioxidant contents. Sesame oil contains sesamin, sesamolin and sesaminol lignan fractions, which are known to play an important role in its oxidative stability and antioxidative activity. It is widely known as one of the natural health-promoting foods that have the potential to prevent various disorders such as hypertension, hypercholesterolemia cancer and aging. Additionally, sesame oil may be useful in handling oxidative stress-associated diseases such as atherosclerosis, diabetes mellitus, obesity, chronic renal failure, rheumatoid arthritis, and neurodegenerative diseases including Alzheimer's disease. Furthermore, sesame oil has multiple physiological functions such as decreasing blood lipids and arachidonic acid levels, increasing antioxidative ability and γ-tocopherol bioavailability, and providing anti-inflammatory function and potential estrogenic activity. Several health-promoting effects are attributed to its lignans. Hence, this article highlights and discusses the potential health-endorsing effects of sesame and its oil with prominence on the role of lignans.

 

Author (s) Details

 

Philip John Kanu
Milton Margai Technical University, Goderich, Freetown, Sierra Leone, Institute of Food Technology, Nutrition and Consumer Studies, School of Agriculture and Food Science, Njala University, Sierra Leone and Centre for Development and Safety, Earl Street, Freetown, Sierra Leone.

 

Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v8/3719

Amorphophallus campanulatus: An Untold Story of a Potent Nutraceutical- Part I| Chapter 14 | Current Overview on Pharmaceutical Science Vol. 2

 The study aims to resolve the proximate arrangement, mineral and vitamin content in addition to active parts present in the popularly exhausted tuber of West Bengal, Amorphophallus campanulatus. Medicinal plants are potential sources of biomolecules and their analogues have excellent relevance in the readiness of modern cures. They are also good beginning of essential nutrients and minerals that enhance the wellbeing of an individual. On decent supplementation through diet, they can acquire, convert, assign, distribute and pave habit for proper exercise of all the essential components in the organic system So this popular tuberous crop of on west side when facing north-east Asia that has allure mention in the Indian ancient curative system, Ayurveda, is captured into consideration to analyze allure nutritional parts. The plant species were composed from farmers of Santragachhi, Howrah district and verified by Botanical Survey of India, Howrah district, West Bengal, India. Fresh tubers were resolved for their content of crude proteins, total oxygen, soluble carbohydrate, fat, fibre, ruins, moisture, carotenoids and vitamins. With the aid of an inductively connected plasma tiny spectrometer, the ash's mineral content was resolved. Phytochemical constituents were divided using smoke chromatography and components discovered by mass spectrometry. According to the study, Amorphophallus campanulatus tubers have high levels of rude protein, moisture, fibre, ruins, and vitamins E and C. In addition, the tuber holds practically all of the necessary large-scale- and micronutrients. It's fascinating that the vegetable is a significant temporary of salt, potassium, and calcium. Additionally, the tuber is exhausted heavy metals containing arsenic, lead, cadmium and mercury. None the less the vegetable also holds several nutraceutical components that have various health benefits. Thus, the study's verdicts make a important contribution to our understanding of the full pertaining to food profile concerning this tuber, that may encourage raised use for the maintenance of a active lifestyle and future consideration to its therapeutic potential.

Author(s) Details:

Subhashree Basu,
Department of Physiology, Tamralipta Mahavidyalaya, Tamluk, Purba Medinipur: 721636, India.

Moumita Das,
Department of Applied Nutrition and Dietetics, Sister Nivedita University, Kolkata, West Bengal, India.

Gouriprosad Datta,
Department of Physiology, Rammohan College, 85A, Raja Rammohan Sarani, Kolkata: 700009, West Bengal, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9293

Nutritional and Biological Profile of Citrullus colocynthis | Chapter 4 | Challenges and Advances in Pharmaceutical Research Vol. 7

 This chapter has information on the proximate analysis, mineral content, and therapeutic uses of Citrullus colocynthis. It is frequently referred to as a bitter apple (Family: Cucurbitaceace). Nutrients like Ash (2-4.48%), Fats (20.7-26.6%), Moisture (4.4-4.91%), Fiber (1.1-52.0%), and Carbohydrates (13.7-70.17%) are abundant in the various portions of bitter melon. Crude protein concentration ranged from 3.68 to 18.83% in different regions, followed by crude fibre (1.84 to 15.13%) and moisture (5.85 to 10.11%), in that order. Following calcium in order of traces were potassium, magnesium, iron, zinc, manganese, phosphorus, sodium, and copper. It contains a lot of amino acids, particularly the important ones. It has long been well known for its medicinal uses, including as a snake poison as an anthelmintic, diuretic, anti-cancer, and anti-diabetic.

Author(s) Details:

Faruk Alam,
Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati, Assam-781026, India.

Moidul I. Judder,
Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, Guwahati, Assam 781035, India.

Please see the link here: https://stm.bookpi.org/CAPR-V7/article/view/8367

Possible Anti-cardiovascular Boosting Properties of Sphenostylis stenocarpa Seed Oil and Milk on Salt Loading-induced Hypertension in Rats | Chapter 06 | Current Topics on Chemistry and Biochemistry Vol. 1

 Legumes have been demonstrated to have high nutraceutical potential, making them a good source of nutrients that are good for human health. Cardiovascular diseases (CVDs), which have been one of the leading causes of death in middle and high-income countries, can be avoided by protecting the heart from malfunctioning. In 2015, 82 percent of the 17 million early deaths (before the age of 70) owing to noncommunicable illnesses occurred in middle and high income nations, with CVDs accounting for 37 percent. The primary prevention of risk factors is the most effective method for preventing cardiovascular disease. Most cardiovascular illnesses can be avoided by implementing population-wide programmes to address behavioural risk factors such cigarette use, poor diet and obesity, physical inactivity, and problematic alcohol consumption. People who have cardiovascular diseases or are at high cardiovascular risk (due to the existence of one or more risk factors such as hypertension, diabetes, hyperlipidemia, or previously established disease) require early detection and therapy, which may include counselling and medications. Sphenostylis stenocarpa (Hochst. ex. A. Rich) Harms is an orphan legume crop whose oil and milk considerably (p 0.05) reduced the atherogenic index of plasma (AIP), a robust marker for predicting the risk of cardiovascular disease, when given to hypertensive albino rats. Rats were given a saturated NaCl solution to produce hypertension. The rats were given varied concentrations of the extracted oil and milk. It was discovered that Sphenostylis stenocarpa seed has a low glycaemic index and that it reduced AIP considerably (p 0.05) at various doses and times.

Author(S) Details

Nwankwo Michael Olisa
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria.

Ogbonna Innocent Okonkwo
Department of Microbiology, Federal University of Agriculture, Makurdi, Nigeria.

Yila Lakabra David
Department of Biochemistry, Federal University of Agriculture, Makurdi, Nigeria.

View Book:- https://stm.bookpi.org/CTCB-V1/article/view/6525

Assessment of Antibacterial Susceptibility Profiles of Gongronema latifolium Extracts and Alum against Clinical Bacterial Pathogens | Chapter 12 | Recent Progress in Microbiology and Biotechnology Vol.2

 The antimicrobial susceptibility test for Gongronema latifolium extracts in combination with potash alum (Alum) was tested using disc diffusion (DD) and Agar well diffusion (AWD) protocols against some clinical bacterial pathogens. Until application, ethanolic and methanolic leaf extracts at concentrations of 0.1-0.3 g were reconstituted in sterile distilled water and 1.0-3.0 g of potash alum. In vitro bioactivity of different extract concentrations and, in combination with alum, measurements of the diameter of inhibition zones (DIZs) were evaluated. The highest inhibition zones for Escherichia coli (14.5±0.5) and Salmonella typhi (11.5±0.0 mm) with enhanced bioactivity of 19.5±0.7 and 17.5±0.7 mm with potash alum against Bacillus subtilis, Sal. were obtained with methanolic leaf extract (MLE). By DD and AWD processes, respectively, typhi and Pseudomonas aeruginosa. Aqueous leaf extract (ALE) and ethanolic leaf extract (ELE), however, and their extracts Combinations of the pathogens displayed strong antibacterial activity but were incomparable to MLE. Bioactivity improvement was achieved with the addition of Alum to leaf extracts on a dose response fashion, particularly by the AWD process, irrespective of the solvent of extraction. In addition , the low MIC values of < 0.05 to 0.2mg / ml for MLE and ALE bacteria confirm their potency and wide spectrum activity. Ciprofloxacin (CP)'s very large DIZs, on the other hand, reflect the beneficial effect of distilled chemotherapeutics against pathogens. The increased efficacy of these natural material extracts, such as potash alum, would also justify potential applications in ethnomedicine, nutraceuticals, pharmaceuticals and food systems.

Lawrence O. Amadi
Department of Microbiology, Faculty of Science, Rivers State University, P.M.B. 5080, Nkpolu-Oroworukwo, Port Harcourt, Nigeria and Department of Microbiology, School of Applied Science, Ken Saro-Wiwa Polytechnic, P.M.B. 20, Bori, Rivers State, Nigeria.

Nathaniel N. Ngerebara
Department of Microbiology, School of Applied Science, Ken Saro-Wiwa Polytechnic, P.M.B. 20, Bori, Rivers State, Nigeria.

Chidinma A. Okafor
Department of Microbiology, School of Applied Science, Ken Saro-Wiwa Polytechnic, P.M.B. 20, Bori, Rivers State, Nigeria.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/278