Incidental Identification of Krukenberg’s Tumour (KT): A Histopathological Perspective | Chapter 2 | Medical Science: Updates and Prospects Vol. 2

 

Krukenberg’s tumour (KT) is a metastatic ovarian malignancy characterised by bilateral ovarian enlargement and a nodular pattern of infiltration on radiology. KTs can be synchronous, where the metastasis is discovered within 3 months of the diagnosis of the primary tumour, or metachronous, where the metastasis is found after 3 months, frequently after the completion of initial therapy. This case report discusses an incidental diagnosis of Krukenberg’s Tumour (KT). A 48-year-old female was incidentally diagnosed with a Krukenberg tumour, involving the entire uterus, uterine leiomyomas, bilateral ovaries and fallopian tubes without any gross enlargement or cystic change in the ovaries. The patient underwent surgery to alleviate the symptoms associated with multiple uterine fibroids detected on ultrasound. She underwent a total abdominal hysterectomy with removal of both the adnexa, along with myomectomy. However, when the ovaries are not enlarged, and complaints of abdominal discomfort or pain are attributable to a fibroid, the possibility of a Krukenberg tumour is seldom considered. Under such circumstances, histopathology examination serves as the only tool to clinch the diagnosis because of its characteristic microscopic features. Recognition of KT is of paramount importance, as it alters both the management approach and prognostic outlook. Furthermore, it is also crucial to exclude mimics, especially tumours with mucinous differentiation, using ancillary techniques like special stains, immunohistochemistry and previous historical details for confirmation.

 

 

Author(s) Details

 

Kriti Chauhan
Metropolis Healthcare Ltd., India.

 

Aastha Sharma
Metropolis Lab Pvt. Ltd., India.

 

Gagandeep Singh
Dr. Singh Path Lab, Ropar, Punjab, India.

 

Please see the book here :- https://doi.org/10.9734/bpi/msup/v2/6598

 

Choosing between FNAC and Core Needle Biopsy: A Battle in Breast Carcinoma Diagnosis | Chapter 5 | Advancement and New Understanding in Medical Science Vol. 6

The present study was conducted in a tertiary care teaching hospital to evaluate the role of FNAC and CNB in diagnosis of suspicious breast cancer by keeping mastectomies- surgical excision (SE) as gold standard. Breast cancer is the commonest female malignancy worldwide. The management of breast carcinoma relies heavily on the diagnostic parameters. Over the years there has been a steady decline in the usage of fine needle aspiration cytology (FNAC) over more popular core needle biopsy (CNB). This was a prospective study done in the department of Pathology of a tertiary care teaching hospital catering to the urban as well as rural population in northern part of India. A total of 60 patients were subjected to simultaneous on site FNAC and CNB. Histopathological correlation (SE) was available in half of the cases only (30 cases). While the Cytological grading was done according to Robinson grading system; the histopathological grading was done by Nottingham Modification of Scarff-Bloom Richardson method. FNAC diagnosed 29 cases whereas CNB diagnosed only 26 cases as malignant with 3 cases signed out as non-diagnostic for malignancy owing to non-sampling from the representative areas. On comparing, FNAC and CNB; agreement was not statistically significant (p=0.14) Comparison of CNB and SE; in 17 cases agreement were noted for both CNB and SE and statistically the values were highly significant (p=0.0001). On comparison of FNAC and SE in 13 cases agreement was noted for both FNAC and SE and the data was statistically significant (p=0.035). It is concluded that FNAC gives 100% results, it is quite reliable investigation and CNB should be done as an adjunct if needed especially for grading of the tumor and for immunohistochemistry.

Author(s) Details:

Parul Garg,
Department of Immunohematology and Blood Transfusion, GGS Medical College and Hospital, Faridkot, India.

Harjot Kaur,
Department of Pathology, SGRDIMSR, Sri Amritsar, India.

Neetu Kukar,
Department of Immunohematology and Blood Transfusion, GGS Medical College and Hospital, Faridkot, India.

Ishwer Tayal,
Department of Forensic Medicine and Toxicology, GGS Medical College and Hospital, Faridkot, India.

Please see the link here: https://stm.bookpi.org/ANUMS-V6/article/view/13356

A Rare Case of Myoid Hamartoma Masquerading as Invasive Breast Carcinoma | Chapter 12 | Advancement and New Understanding in Medical Science Vol. 5

Breast Myoid Hamartoma (MH) is a rare type of neoplasm with a poorly understood pathogenesis. Very few literatures have reported such disease with an unclear prognosis and malignant potentiality. Some isolated studies have shown that breast Myoid Hamartoma (MH) may be genetically related to other types of tumours with the involvement of HMGA2 gene. We reported a case of a 64-year-old post-menopausal lady with an underlying chronic idiopathic axonal polyneuropathy (CIAP) that was referred to our centre for a suspected right breast tumour. Clinical and imaging proved the disease to be malignant, however, core biopsy results showed otherwise. Ultrasound of the right breast showed a solid mass with a hypoechoic heterogeneous echotexture and posterior shadowing. A Mammogram highlighted a dense lesion in the right breast with radiolucent halo and macrocalcification. It was reported as BIRADS 4 category. Managing breast Myoid Hamartoma (MH) is proved to be of great challenge to clinicians as meticulous clinical acumen is needed to strategize a proper plan and management, most importantly, not to overlook the disease as the malignant transformation has been reported before.

Author(s) Details:

Mohamed Shafi Mahboob Ali,
Department of General Surgery, Advanced Medical and Dental Institute (AMDI), Malaysia.

Please see the link here: https://stm.bookpi.org/ANUMS-V5/article/view/13341

Current Trend in the Cancer Symptoms | Chapter 8 | Current Progress in Medicine and Medical Research Vol. 9

This Chapter chiefly focuses on Cancer related manifestations in the diagnosed case and non distinguishing symptoms of tumor and also in the non curable malignancy Patient.  It also shows the appearance of such syndromes in the pre and post Chemotherapy, Radiation therapy and in Surgical Intervention for the inmates undergoing Cancer Treatment.Cancer being the 2nd chief cause of mortality in the experience is a major public concern can influence any part of the crowd. Breast cancer in the women and prostrate cancer in the men are most commonly happening form of the Cancer. As it is diagnosed late in the underdeveloped countries higher rates of allure occurrence are found.Cancer accompanying symptoms like Anxiety, despair, psychological disorders, sleep disorder, fatigue, pain and working impairment. Cancer sufferers suffer from extreme burden of these symptoms that could happen as complications, initially following in position or time therapy or all along long term healing may last from months to age. This leads to feeling of incompetence and hopelessness that can seriously influence the quality of life.

Author(s) Details:

Noel Samuel Macwan,
College of Physiotherapy, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat, 391760, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11692

Study on Mammographic Breast Pattern in Postmenopausal Women in Ibadan, South-Western Nigeria | Chapter 1 | Issues and Development in Health Research Vol. 1

 The density of mammograms is a powerful predictor of breast cancer. Menopause has a substantial impact on breast pattern and has been shown to have a greater impact on mammographic density reduction than age. The goal of this study was to investigate breast parenchymal density patterns in postmenopausal women in Ibadan and connect them with socio-demographic and anthropometric data. Methodology: This is a retrospective cross-sectional study of 196 postmenopausal women who underwent two screening views on each breast at the University College Hospital Ibadan's Radiology Department. Data was taken from a questionnaire filled out by patients who had a mammogram during the time period under consideration. The mammography reports were matched with the patients' sociodemographic information and analysed using the R statistical software. The women's mean age at menopause was 48.44.6 years, and their mean age at menopause was 55.06.8 years. 82.1 percent of the women had the combined BI-RADS 1 and 2 breast parenchymal patterns, which are linked to a lower risk of breast cancer. The difference in average age at first birth between women with BI-RADS 1 and 2 and women with BI-RADS 3 and 4 was statistically significant (P=0.035). Although not statistically significant, BMI, family and personal history of breast cancer all exhibited a link with breast parenchymal pattern. Conclusion: The study's findings of a low prevalence of dense breast pattern are consistent with earlier findings of a reduced prevalence of breast cancer in African women. The clustering of low mean age at first childbirth, low mean age at menopause, and multi-parity in the majority of the women in this study, in combination with low mammographic density, further supports the significantly lower risk of breast cancer in our study population.

Author (s) Details

O. S. Bassey
Department of Radiology, University College Hospital, Ibadan, Nigeria and Department of Radiology, Nile University of Nigeria, Abuja.

T. O. Soyemi
Department of Radiology, University College Hospital, Ibadan, Nigeria.


A. T. Adeniji-Sofoluwe
Department of Radiology, University College Hospital, Ibadan, Nigeria.

A. O. Adeoye
Department of Pathology, University College Hospital, Ibadan, Nigeria.

O. A. Mosuro
Department of Family Medicine, University College Hospital, Ibadan, Nigeria.

T. S. Akingbola
Department of Hematology, University College Hospital, Ibadan, Nigeria.

O. O. Osofundiya
Department of Radiology, University College Hospital, Ibadan, Nigeria.

G. O. Obajimi
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.


A. O. Oluwasola
Department of Pathology, University College Hospital, Ibadan, Nigeria.

M. O. Obajimi
Department of Radiology, University College Hospital, Ibadan, Nigeria.

O. I. Olopade
Department of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois, USA.


View Book :- https://stm.bookpi.org/IDHR-V1/article/view/2152

Pattern of Ultrasonographic Breast Findings in a Tertiary Hospital in North-Central Nigeria | Chapter 14 | Research Trends and Challenges in Medical Science Vol. 4

Introduction: Radiological examination of the breast is established as an essential part of the modern multidisciplinary approach to effective investigation and management of breast disease. Ultrasonography of the breast plays a prominent role in radiological management of breast lesions. Methods: The study was a retrospective analysis of all the breast ultrasound scan at the Jos university Teaching Hospital (JUTH), Jos, Plateau State. Over a one year period of January 2nd 2013January 2nd 2014. All the breast ultrasound scan results were retrieved from the archive of the department after necessary approval. Information soughts for included patient age, sex, indications for the scanning and outcome of the scanning. Results: Women constituted 88.56% of the 201 patients scanned. There was an increase in the age of the patients to the age group of 20-29 after which, there was a steady decline? Fibroadenoma was the highest indication and the second highest finding. There was a good relationship between indications and findings, with a p value of 0.001. Conclusion: It was noted that younger age groups had more breast US, in which benign lesions constituted the major abnormal findings. Most of the males US scans were abnormal compared to females. The clinico-radiological correlation was significant.

Author(s) Details

Dr. A. J. Salaam 
Department of Radiology, Jos University Teaching Hospital, P.O.Box 1363, Jos, Nigeria.

S. M. Danjem
Department of Radiology, Jos University Teaching Hospital, P.O.Box 1363, Jos, Nigeria

Dr. A. A. Salaam 
Department of Family Medicine, Jos University Teaching Hospital, P.O.Box 1363, Jos, Nigeria.

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/212