Quinolones, a well-established class of synthetic antibacterial agents, have long been valued for their broad-spectrum efficacy against a range of bacterial pathogens. Originally developed to target bacterial DNA gyrase and topoisomerase IV, these compounds have undergone extensive structural modifications over the decades, enhancing their potency, spectrum of activity, and pharmacokinetic properties. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had activity against aerobic gram-negative bacteria, newer quinolones have wider potential applications and a broader spectrum of activity. Recently, some of the newer quinolones such as sparfloxacin, enoxacin, and moxifloxacin have been reported concerning the cytotoxic effects on transitional cell carcinoma of the bladder, colorectal carcinoma, prostate cancer cells and also active against mycobacterium tuberculosis. This chapter explores the historical development, chemical evolution, and pharmacological reorientation of quinolones, highlighting their mechanistic versatility and the growing body of evidence supporting their anticancer potential. By tracing the scientific milestones from antibacterial to anticancer applications, this chapter provides a comprehensive overview of quinolones’ therapeutic journey and underscores their significance in modern drug repurposing strategies.
Author
(s) Details
Ajay
Gadgul
Dayanand Education Society’s, Dayanand College of Pharmacy,
Latur-413512, India.
Mahesh
Birajdar
Dayanand Education Society’s, Dayanand College of Pharmacy,
Latur-413512, India.
Sameep
Sonvane
Dayanand Education Society’s, Dayanand College of Pharmacy,
Latur-413512, India.
Yogesh
Kulkarni
Dayanand Education Society’s, Dayanand College of Pharmacy,
Latur-413512, India.
Kranti
Satpute
Dayanand Education Society’s, Dayanand College of Pharmacy,
Latur-413512, India.
Please see the book here:- https://doi.org/10.9734/bpi/cbrp/v6/5652
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