Background: Artificial sweeteners have spread throughout diets, serving as essential components in various food and beverage products. Sucralose, one of the newest artificial sweeteners was approved by the Food and Drug Administration in 1998. Saccharin is also a non-nutritive, non-caloric intense artificial sweetener.
Aim of the Study: This study aimed to determine the effects
of sucralose and sodium saccharin on some physiological parameters in male
albino rats.
Materials and Methods: Thirty male albino rats weighing from
100 to 120 gm were used. The period of the experiment was 30 days. The animals
were divided into three groups, Group 1: control, Group 2: rats received
sucralose and Group 3: rats received sodium saccharin. The following parameters
were processed: serum glucose, ASAT, ALAT, serum creatinine, serum urea,
protein and lipid profiles and hormonal levels (insulin, testosterone, serum T3
and T4). Data were analyzed by using a T-test and were performed using the
Statistical Package (SPSS) program, version 20. The Bonferroni test was used as
a method to compare significance between groups.
Results: There was an increase in ASAT and ALAT activities,
serum creatinine and serum urea levels in group 2 and group 3, and lipid
profile in the group that received sucralose (TC, HDL and LDL) and T3&T4 in
the group that received saccharin as compared to the control group. Meanwhile,
a drop in serum glucose, insulin, total protein, albumin, albumin/globulin
ratio and triglycerides in group 2 and group 3, and lipid profile in the group
received saccharin (TC, HDL and LDL) and T3&T4 in the group received
sucralose was observed when compared to the control group. The impact of
artificial sweeteners on human health is still a matter of doubtful dispute.
Conclusion: It can be mentioned that sucralose and sodium
saccharin must be carefully used because they have very dangerous effects,
especially sodium saccharin, and people have to replace them with natural
sugar.
Author (s) Details
Eman G.E. Helal
Department of Zoology, Faculty of Science (Girls), Al-Azhar University,
Egypt.
Abdullah Al-Shamrani
Department of Pediatric Pulmonology and Sleep Medicine, Prince Sultan
Medical Military City, King Saud bin Abdulaziz University and Health Science,
Saudi Arabia.
Mohamed A. Abdelaziz
Department of Medical Physiology, Faculty of Medicine, Al-Azhar University,
Egypt.
Mariam S. El-Gamal
Department of Zoology, Faculty of Science (Girls), Al-Azhar University,
Egypt.
Please see the book here:-https://doi.org/10.9734/bpi/cbrp/v2/4114
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