The Effect of Sucralose and Sodium Saccharin as Artificial Sweeteners on Some Biochemical Parameters in Male Albino Rats | Chapter 8 | Chemistry and Biochemistry: Research Progress Vol. 2

Background: Artificial sweeteners have spread throughout diets, serving as essential components in various food and beverage products. Sucralose, one of the newest artificial sweeteners was approved by the Food and Drug Administration in 1998. Saccharin is also a non-nutritive, non-caloric intense artificial sweetener.

Aim of the Study: This study aimed to determine the effects of sucralose and sodium saccharin on some physiological parameters in male albino rats.

Materials and Methods: Thirty male albino rats weighing from 100 to 120 gm were used. The period of the experiment was 30 days. The animals were divided into three groups, Group 1: control, Group 2: rats received sucralose and Group 3: rats received sodium saccharin. The following parameters were processed: serum glucose, ASAT, ALAT, serum creatinine, serum urea, protein and lipid profiles and hormonal levels (insulin, testosterone, serum T3 and T4). Data were analyzed by using a T-test and were performed using the Statistical Package (SPSS) program, version 20. The Bonferroni test was used as a method to compare significance between groups.

Results: There was an increase in ASAT and ALAT activities, serum creatinine and serum urea levels in group 2 and group 3, and lipid profile in the group that received sucralose (TC, HDL and LDL) and T3&T4 in the group that received saccharin as compared to the control group. Meanwhile, a drop in serum glucose, insulin, total protein, albumin, albumin/globulin ratio and triglycerides in group 2 and group 3, and lipid profile in the group received saccharin (TC, HDL and LDL) and T3&T4 in the group received sucralose was observed when compared to the control group. The impact of artificial sweeteners on human health is still a matter of doubtful dispute.

Conclusion: It can be mentioned that sucralose and sodium saccharin must be carefully used because they have very dangerous effects, especially sodium saccharin, and people have to replace them with natural sugar.

 

Author (s) Details

 

Eman G.E. Helal
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt.

 

Abdullah Al-Shamrani
Department of Pediatric Pulmonology and Sleep Medicine, Prince Sultan Medical Military City, King Saud bin Abdulaziz University and Health Science, Saudi Arabia.

 

Mohamed A. Abdelaziz
Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Egypt.

 

Mariam S. El-Gamal
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt.

 

Please see the book here:-https://doi.org/10.9734/bpi/cbrp/v2/4114

Role of Minerals, Magnesium and Zinc in Subclinical Hypothyrodisim| Chapter 9 | Current Topics on Chemistry and Biochemistry Vol. 6

 This study aim to estimate the levels of antitoxin magnesium and zinc in inmates of Subclinical Hypothyroidism (SCH). SCH, according to the endocrine netting is defined as an promotion in Thyroid Stimulating Hormone (TSH) level (4.6-10 m I U/L) with thyroid birth control method levels in the normal range. The party needs magnesium (Mg+2), a macromineral that serves as a cofactor for more than 300 enzymes. For 5'-deiodinase to work correctly and as a cofactor for thyrotropin-surrendering hormone (TRH), metallic mineral (Zn+2) is necessary. The thyroid hormones that copy factors bind to and involve Zn+2 bound to cysteine residues are essential for modulating deoxyribonucleic acid expression.To recognize the instances with SCH, the antitoxin TSH, Total Triiodothyronine (T3), and Thyroxine (T4) levels were determined utilizing the ELISA method. By spectrophotometry, a semiautomated analyst was used to determine the antitoxin magnesium concentration. Patients accompanying SCH had their serum metallic mineral judged using a sufficiently automated analyst (Vitros 5600).In SCH, both T3, T4 were inside the normal range, and TSH was in the range of 4.6-10 mI U/L. There was a statistically meaningful (p0.001) drop in antitoxin zinc levels, but not in antitoxin magnesium levels in patients accompanying subclinical hypothyroidism.

Author(s) Details:

Thuraya Abdulsalam A. A. Al-Azazi,
Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

Shaliza Verma,
Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

Rajesh Kr Thakur,
Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

Manoj Kumar Nandkeoliar,
Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

V. P. S. Punia,
Department of Medicine, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

B. C. Kabi,
Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital, Sharda University, Greater Noida, Uttar Pradesh, India.

Please see the link here: https://stm.bookpi.org/CTCB-V6/article/view/8777