Aims: Development of a general concept for creating mesoporous
silica nanocontainers (MSNs), that ensures the combination of the stages of
their sol-gel synthesis and loading with several drugs (including hydrophobic
ones) and evaluation of the prospects of creation of bionanocomposites based on
such MSNs.
Methodology: When creating MSNs, hybrid templates are used, which
are micelles of amphiphilic drugs with a hydrophobic biologically active
compound (curcumin, quercetin, etc.) solubilized in them. During the study, two
groups of problems were solved. The first of them consisted of studying the
features of the formation of such templates, establishing the influence of the
conditions of MSNs synthesis on their morphology and loading capacity, as well
as determining the factors that control the rate of encapsulated drugs’
release. The second group includes problems related to the creation of
nanocomposites based on MSNs and the biocompatible polysaccharide sodium
alginate, the study of their properties, and the assessment of biological
activity.
Results: Solubilization of hydrophobic bioactive compounds in
micelles of amphiphilic drugs (e.g. antiseptics), belonging to the class of
cationic surfactants, is a thermodynamically favorable process that greatly (up
to 80 times) enhances the solubility of such compounds in water. Sol-gel
synthesis on such hybrid templates leads to the formation of bifunctional MSNs
characterized by a narrow size distribution, a pronounced porous structure, and
a high loading capacity. The release rate of both encapsulated drugs can be
controlled by the changing medium pH. The possibility of creating antibacterial
nanocomposites with prolonged action was demonstrated when using MSNs obtained
on micelles of the amphiphilic antiseptic miramistin with solubilized quercetin
as a model.
Conclusion: The proposed approach to creating bifunctional MSNs
can be applied to different compounds. It is of special interest from the point
of view of creating new biomedical materials (primarily for dentistry and
tissue regeneration).
Author(s)
Details
Elena
M. Shishmakova
Frumkin Institute of Physical Chemistry and Electrochemistry of
Russian Academy of Sciences, 119071, Moscow,
Russia.
Anastasia
V. Bolshakova
Frumkin Institute of Physical Chemistry and Electrochemistry of
Russian Academy of Sciences, 119071, Moscow, Russia and Moscow State
University, 119992, Moscow, Russia.
Ekaterina
K. Urodkov
Frumkin Institute of Physical Chemistry and Electrochemistry of
Russian Academy of Sciences, 119071, Moscow, Russia.
Natalia
E. Grammatikova
Gause Institute of New Antibiotics, 119021, Moscow, Russia.
Victor
M. Rudoy
Frumkin Institute of Physical Chemistry and Electrochemistry of
Russian Academy of Sciences, 119071,Moscow, Russia.
Olga V.
Dement'eva
Frumkin Institute of Physical Chemistry and Electrochemistry of
Russian Academy of Sciences, 119071, Moscow,
Russia.
Please see the book here:- https://doi.org/10.9734/bpi/prrat/v4/1334
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