In this study, four complexes featuring the [ReO]³⁺ core by substituting precursors RO(citrate)₂⁻ and ReO(gluconate)₂⁻ were synthesized. The complex [ReO(MBT)₂OH] was obtained through the direct reduction of ReO₄⁻ using sodium borohydride as the reducing agent. Characterization of these complexes was conducted using UV-Vis and IR spectroscopy, elemental analysis, 1H and 13C NMR spectroscopy, thermogravimetric analysis (TGA), and density functional theory (DFT) calculations.
At the technetium tracer level, a 99mTcO-complex was synthesized
using 99mTc-gluconate as a precursor. The radiochemical purity of the complex
exceeded 95%, as measured by thin-layer chromatography. In vitro studies
demonstrated that the complex exhibited good stability under physiological conditions,
with a partition coefficient indicating its hydrophilic nature. Biodistribution
studies in mice revealed significant heart accumulation, with uptake at
10.23±3.87% ID/g at 5 minutes and good retention at 6.86±1.21% ID/g at 60
minutes. One-hour post-injection, the heart/liver, heart/lung, and heart/blood
radioactivity ratios were 0.71, 1.1, and 0.95, respectively. These findings
suggest that the complex may be suitable for myocardial imaging.
Author
(s) Details
Noura
AlHokbany
Department of Chemistry, College of Science, King Saud University,
Riyadh, Kingdom of Saudi Arabia
Ibrahim
AlJammaz
Cyclotron and Radiopharmaceuticals Department, King Faisal
Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Please see the book here:- https://doi.org/10.9734/bpi/cmsdi/v10/4042
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