Type 1 Diabetes Mellitus (DM) in adults is currently more common than in children, as traditionally thought. The new data show that up to 40% of Type 1 DM in adults above the age of 30 is misdiagnosed as type 2 DM. The reason for this is that Type 1 DM in adults has a slightly different clinical presentation, usually is not as acute as in children, and can have a short period in which insulin is not needed, generally less than 6- months compared to Latent autoimmune diabetes in adults (LADA). The other reason is that the physicians think that if DM is diagnosed above 40, the patients have DM type 2. This was the traditional way of thinking in the past. Also, 61% of patients with Type 1 DM are overweight and/or obese, which further makes the clinical diagnosis more difficult.
In our case series we are describing two patients misdiagnosed for
14- years one of them and for 4- years the other one as having DM type 2.
They were, from the beginning of their Disease treated with
Insulin and other oral antidiabetic medications as well as injectable GLP1-RAG
and had very brittle DM, admissions in the hospital for DKA’s, and inferior
control of their disease.
Both of them had DKA as the initial presentation of their DM.
We saw those two patients in the clinic and proved that they have
adult-onset type 1 DM by checking their GAD-65, IA-2, and Zn- T8 antibodies,
which were very positive and showing that their C-peptide was undetectable
while their plasma glucose was between 80-180 mg/dl. We treated them with a
Basal bolus Insulin regimen and stopped other oral or injectable antidiabetic
medications. We switched them from self-monitoring their blood Glucose (SMBG)
four times a day to Continuous Glucose monitoring (CGM) with the devices Dexcom
G6 and Dexcom G7. The patients were sharing their CGM data with our Internal
Medicine Residency clinic. The Internal medicine Residents, part of the CGM
team under the supervision of a Certified Endocrinologist who was a part of the
clinic, were adjusting their Insulin bi-weekly and seeing the patients every
two months. The control of their adult-onset DM type 1 improved significantly
after the right diagnosis had been given and CGM introduced.
Author
(s) Details
A. Manov
Department of Internal Medicine, Mountain View Hospital, Sunrise Health
Graduate Medical Education Consortium, Las Vegas, Nevada, USA.
S. Chauhan
Department of Internal Medicine, Mountain View Hospital, Sunrise Health
Graduate Medical Education Consortium, Las Vegas, Nevada, USA.
G.Dhillon
Department of Internal Medicine, Mountain View Hospital, Sunrise Health
Graduate Medical Education Consortium, Las Vegas, Nevada, USA.
A. Donepudi
Department of Internal Medicine, Mountain View Hospital, Sunrise Health
Graduate Medical Education Consortium, Las Vegas, Nevada, USA.
Please see the book here:- https://doi.org/10.9734/bpi/acmms/v12/3912
No comments:
Post a Comment