An experiment was conducted to investigate the effects of
gossypol on growth of animal cells in culture. A cells culture was established
according to the methods of Freshney (2010). Four treatments examined were To=
cells + media, Te= cells + ethanol, Tgl= cells + 5 µM gossypol, and TgH= cells +
20 µM
gossypol. The results of this experiment indicated that the presence of
gossypol 5 µM
inhibited (p<0.01) cells growth, and gossypol at 20 µM completely stopped the
increased in the numbers of cells. It was concluded that the division and
growth of animal cells in culture were adversely depressed by gossypol probably
due to gossypol-protein complexes which enveloping cells, preventing protein
transferred from media to cells, and reduced the nutrient availability for
growth.
Author(s)details:-
Ismartoyo
Department of Animal Science, Hasanuddin University, Makassar-90245, Indonesia.
Please See the book
here :- https://doi.org/10.9734/bpi/ibs/v5/577
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