Introduction:
Pyrethroid based mosquito vaporisers are commonly used as Personal Protective
Measures (PPM) to avoid mosquito-borne diseases. Effective control of
mosquito-borne diseases with the use of general public health measures is yet
to be achieved in our country, so there is increasing use of PPM like mosquito
coils, liquid vaporisers, mats, and insecticide-treated bed nets in the Indian
population but data regarding the safety profile of PPM is still scarce.
Curcumin is the main biologically active phytochemical component of turmeric. Extensive
studies within the last half a century have demonstrated the protective action
of curcumin in almost all the disorders of the body. The molecule is known to
possess anti-oxidative, anti-inflammatory, antimicrobial, anti-cytotoxic and
many other useful properties. The molecule is known to possess neuroprotective
properties as well [1].
Aim: To analyse
the change in the body weight of male albino wistar rats exposed to pyrethroid
based mosquito vaporizers and the protective role of turmeric with withdrawal
effect.
Materials and Methods:
This was an experimental study on a total of 24 male albino Wistar rats from
July 2015 to October 2016. They were randomly divided into groups I, II, III
and IV. Each group contained six rats. Group I animals served as control, Group
II animals were exposed to mosquito vaporiser, 8 hours/day for six days in a
week for 90 days, Group III received the same treatment as group II and
thereafter retained for 4 weeks of withdrawal to see the reversal changes and
Group IV is exposure along with turmeric administration in a dose of 20mg/kg
body weight orally. The data was analysed using Statistical Package for Social
Sciences (SPSS) version 21.0. Comparison of body weight among different groups
at different time intervals is done by paired t-test. A p-value less than 0.05
was considered to be significant.
Results:
Pyrethroid exposure results in reduced weight gain in exposed group rats. The
mean difference in body weight between groups I and II, I and III and I and IV
at the end of study was 37.32±24.47gm (p=0.443), 42.02±24.47gm (p=0.343) and
8.29±25.67gm (p=0.988). Weight gain in all the group rats was almost similar
till the 8th post-exposure week, after that from the 9th week onwards
decremented trend in weight was seen in groups II and III but the group IV rats
showed an increasing trend in weight gain.
Conclusion: The
assessment suggests that inhalation of pyrethroid based mosquito vaporisers
fumes has toxic effects, reflected as reduced weight gain following subchronic
exposure and one-month withdrawal is not a sufficient time to overcome the
damage induced by pyrethroids. Turmeric shows a protective effect which is
reflected in the form of weight gain.
Author(s)details:-
Swati Yadav
Department of Anatomy, Hind Institute of Medical Sciences, Mau, Ataria,
Sitapur, Uttar Pradesh, India.
Rakesh Kumar Dewan
Department of Anatomy, King George’s Medical University, Lucknow, Uttar
Pradesh, India.
Anita Rani
Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh,
India.
Jyoti Chopra
Department of Anatomy, King George’s Medical University, Lucknow, Uttar
Pradesh, India.
Please See the book
here :- https://doi.org/10.9734/bpi/ibs/v5/8519E
No comments:
Post a Comment