Introduction: Type II diabetes is a chronic disease which
results from aspects such as complex inheritance interaction, obesity, and
sedentary lifestyle. In India, diabetes is turning into an epidemic as
currently, 110 million individuals suffer from the disease. To our knowledge,
very few studies have evaluated the correlation between lipid profiles and
glycated hemoglobin (HbA1c) in newly diagnosed type II diabetes and in
diabetics with hypertension. The early detection of lipid abnormalities in
these patients will help prevent the cardiovascular outcomes.
Objectives: To identify the correlation between HbA1c and
lipid profiles among newly diagnosed type II diabetics and in Diabetics with
hypertension, also among Prediabetics in Bengaluru (urban and rural) in
Karnataka (South India); and to study the risk factors for developing
dyslipidemia and cardiovascular diseases.
Methods: This was a cross sectional study involving 424
Individuals in Bengaluru, India from January 2022 to September 2023.
Demographics, lifestyle habits and clinical features were analyzed for the
presence of any interrelationship with the occurrence of dyslipidemia. One-way
analysis of variance (ANOVA), followed by Tukey’s post hoc tests, Chi square
and correlation studies were used to establish a significant level of
association between the study parameters.
Results: Among healthy, prediabetics, Newly Diagnosed type 2
diabetics and type 2 diabetics with hypertension, there were significant
differences in lipid profile parameters- total cholesterol l(TC), triglycerides
(TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very
low-density lipoprotein (VLDL), ratios of cholesterol to HDL(TC:HDL) and ratios
of LDL to HDL(LDL:HDL). A strong correlation between HbA1c and lipid profiles
was established.
Discussion: correlation of glycosylated hemoglobin with
lipid profile components started to appear with the onset of prediabetes phase
itself, increased in case of Diabetics and the maximum correlation was observed
in case of diabetics with hypertension. As per our study, a sedentary
lifestyle, consuming alcohol, smoking, overweight, abdominal obesity were
identified as the risk factors for developing diabetes and eventually
hypertension along with diabetes.
Conclusion: Periodic monitoring of various components of
lipid profile at prediabetic phase itself, along with increased physical
activity, weight control, healthy diet, cessation of alcohol and smoking
prevents dyslipidemia and cardiovascular diseases hence reduces not only
morbidity and mortality but also economic burden.
Author(s) Details:
Rao S. N.,
Department of Biochemistry, AECS Maruthi Dental College, Bengaluru,
Karnataka, India.
Kuldeep G. B.,
Department
of Medicine, Sri Krishna Sevashrama Hospital, Bengaluru, Karnataka, India.
Please see the link here: https://stm.bookpi.org/ANUMS-V6/article/view/13361
No comments:
Post a Comment