Berlinia grandiflora Hutch and Dalz Ethanol Stem Bark Extract Ameliorates the Effect of CCl4 Induced Liver Damage in Rats | Chapter 4 | Pharmaceutical Research: Recent Advances and Trends Vol. 10

The largest organ in the body, the liver, serves as the final organ in biological processes like metabolism, excretion, and detoxification. Hepatocytes are destroyed throughout the procedure, which might lead to problems or liver damage. The objective of the present study was to provide empirical support for the folkloric assertion that the stem bark of Berlinia grandiflora is utilized in the treatment of hepatic disorders. This was achieved by evaluating the effect of the ethanol extract on liver maker enzymes in vivo. Six groups of six Wistar albino rats were selected and each was subjected to different treatments with carbon tetrachloride (CCl4), followed by ethanol stem bark Berlinia grandiflora extract (ESBG) for seven days. At the conclusion of the treatment period, serum biochemical parameters were evaluated to determine the health of the liver. Treatment of rats with ESBG (at doses 100, 300 and 900 mg/kg b.w., orally) reduced the impact of CCl4-induced hepatotoxicity on liver maker enzymes Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and Total Bilirubin (TB), with the 900 mg/kg b.w. showing a significant reduction (p < 0.05) compared to the group treated with only CCl4. Serum Total protein (TP) and albumin (ALB) increased in rats treated with the extracts, with the 900 mg/kg b.w. dose showing a significant increment (p<0.05) compared to the group treated with only CCl4. The study revealed that the ethanol extract of Berlinia grandiflora stem bark was able to ameliorate the effect of CCl4-induced liver damage, thus supporting the traditional usage of the plant in treating liver-related disorders.

 

Author (s) Details

 

Martin Ntiamoah Donkor
Department of Biochemistry and Forensic Sciences, School of Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences, Navrongo, Ghana.

 

Addai-Mensah Donkor
Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana and Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v10/3137

Determination of Blood Serum Lead and Cadmium Level during Pregnancy in Gas Flaring Communities of Bayelsa State Nigeria | Chapter 4 | Recent Developments in Medicine and Medical Research Vol. 12

 The amount of serum lead and cadmium in pregnant and non-pregnant women living in selected gas flaring localities in Bayelsa State, Nigeria is determined and compared in this study. This study included 200 pregnant women who appeared to be in good health and 100 non-pregnant women who served as controls. In non-pregnant and pregnant subjects, the prevalence of elevated serum lead (>0.1ppm) beyond the World Health Organization permitted level was 2% and 5%, respectively, whereas the prevalence of elevated serum cadmium (>0.0012 ppm) was (11.33%) and (19.66%). However, the cumulative prevalence of increased heavy metals in non-pregnant and pregnant patients was 6.66 percent and 6.66 percent, respectively (12.33 percent ). The non-pregnant control group had a non-significant higher concentration of lead (0.07 ppm) than the pregnant (0.05 ppm) group, with no difference in their cadmium (0.01 ppm) levels. The study found a non-significant increase in the level of lead in the pregnant test group (0.06 ppm) during their third trimester as compared to those in their first and second trimesters (0.05 ppm), as well as a non-significant increase in cadmium blood levels (0.02 ppm) in the third trimester. The longer the period of exposure to gas flares in years, the higher the quantity of lead and cadmium in the blood of pregnant and non-pregnant women in Bayelsa state, Nigeria, according to this research.

Author(S) Details

Solomon M. Uvoh
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of port Harcourt, Rivers State, Nigeria.

Arthur N. Chuemere
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of port Harcourt, Rivers State, Nigeria.

Charles Nnamdi Ngaikedi
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of port Harcourt, Rivers State, Nigeria.

E. Kiridi Emily Gabriel
Department of Human Physiology, Faculty of Basic Medical Sciences, Niger Delta University, WILBERFORCE Island Bayelsa State, Nigeria.

View Book:- https://stm.bookpi.org/RDMMR-V12/article/view/4670