Phthalocyanine Photosensitizers towards Drug-Resistant Pathogens | Book Publisher International

 

Phthalocyanine complexes under the research interest belong to the porphyrin-like compounds with a structure that is described as flexible for chemical alterations and unique photo physicochemical properties for the most challenging application fields such as biomedicine and ecology. As a result of visible or near-infrared light excitation in the oxygen atmosphere, cytotoxic oxygen species such as molecular singlet oxygen and others have been produced. The pathogenic cells as a target for these reactive oxygen species could be inactivated and the curative process stand up. The book presents a number of new original phthalocyanine complexes and their studies as photosensitizers for inactivation on pathogenic cells (bacteria, fungi, and viruses). The results showed our efforts to reduce the main limitations of the known photosensitizers with a special focus on the hydrophobicity, drug-delivery, uptake and selectivity of phthalocyanines and not the last the dark toxicity of the composite containing photoactive compound for the optimal PDT-efficiency.

 

Author (s) Details

Vanya Mantareva
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-49970-20-5

Biochemical and Histopathological Changes in the Liver of Oreochromis niloticus Experimentaly Infected with Escherichia coli| Chapter 7 | Research Advances in Microbiology and Biotechnology Vol. 1

 Fish of Oreochromis niloticus were acted with various concentrations of Enterotoxigenic Escherichia coli (ETEC) as (103-105, 106-107 109-1010/ml water). The study was carried out to discover the impact of E. coli toxins on Oreochromis niloticus fish during the whole of physiological liver function and histopathological changes in the liver. The principles of GPT, GOT and alkaline Phosphatase categorized between (905.90 IU/L -75.40 IU/L), (4827.7 IU/L - 385.50 IU/L) and (106- 107 CFU /ml - 103 - 105 CFU / ml) for the three liver enzymes individually. When Oreochromis niloticus liver was exposed to Escherichia coli, it displayed signs of fatty degeneration, ballooning deterioration, pyknotic hepatocyte nuclei, necrosis of the hepatocytes and pancreatic acini, haemorrhage, angering WBC infiltration, and hemosiderin shade buildup. The experiment's verdicts showed that the liver of O. niloticus was intensely vulnerable to E. coli contamination, which caused bigger liver enzyme levels, erratic and irreversible liver damage, and eventually the highest aggregation of mortality.

Author(s) Details:

Amal M. Yacoub,
Biology Department, Science College, Taif University, KSA and Pollution Lab., National Institute of Oceanography and Fisheries, Egypt.

Sherifa Mostafa M. Sabra,
Biology Department, Science College, Taif University, KSA and Department of Microbiology, Animal Health Research Institute, Dokki, Giza, Egypt.

Mona Khaled D. Al-Kourashi,
Biology Department, Science College, Taif University, KSA.

Please see the link here: https://stm.bookpi.org/RAMB-V1/article/view/8987