Phthalocyanine Photosensitizers towards Drug-Resistant Pathogens | Book Publisher International

 

Phthalocyanine complexes under the research interest belong to the porphyrin-like compounds with a structure that is described as flexible for chemical alterations and unique photo physicochemical properties for the most challenging application fields such as biomedicine and ecology. As a result of visible or near-infrared light excitation in the oxygen atmosphere, cytotoxic oxygen species such as molecular singlet oxygen and others have been produced. The pathogenic cells as a target for these reactive oxygen species could be inactivated and the curative process stand up. The book presents a number of new original phthalocyanine complexes and their studies as photosensitizers for inactivation on pathogenic cells (bacteria, fungi, and viruses). The results showed our efforts to reduce the main limitations of the known photosensitizers with a special focus on the hydrophobicity, drug-delivery, uptake and selectivity of phthalocyanines and not the last the dark toxicity of the composite containing photoactive compound for the optimal PDT-efficiency.

 

Author (s) Details

Vanya Mantareva
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-49970-20-5

In-vivo Photothermal and Photodynamic Therapy for Tumors Using a Theranostic Strategy Based on Graphene Oxide | Chapter 8 | Advanced Concepts in Pharmaceutical Research Vol. 7

Cancer is the second leading cause of death globally and is responsible for about 1 in 6 deaths in the world. Therefore, there is a demand to introduce novel, effective antitumor agents delivered to their specific target tissue/site to improve the efficiency of cancer diagnosis and treatment and limit the undesired systemic adverse effects caused by conventional chemotherapeutic agents. In this context, graphene oxide (GO) has garnered interest in biomedicine for cancer therapy due to its distinct physical and chemical properties.

This study describes the in vivo application of Graphene Oxide (nc-GO) nanocomposites whose surfaces have been modified with PEG-folic acid, Rhodamine B, and Indocyanine Green. In addition to displaying red fluorescence spectra of Rhodamine B acting as the fluorescent marker, in vivo experiments were performed using nc-GO to apply Photodynamic Therapy and Photothermal Therapy in the treatment of Ehrlich tumors in mice using Near-Infrared Light (808 nm 1.8 W/cm2).

This study utilized fluorescence images to analyze the tumor, aiming to achieve the highest concentration of nc-GO over time (time after intraperitoneal injection). The resulting time data was then employed to optimize the tumor treatment through PDT / PTT. The current study shows an example of the successful use of nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously In vivo fluorescence diagnostics and combined PDT-PTT effects for cancer treatments.

Author(s) Details:

María Paulina Romero,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil and Departamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Ecuador.

Hilde Harb Buzzá,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Mirian Denise Stringasci,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Bianca Martins Estevão,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Cecília de Carvalho Castro e Silva,
MackGraphe, Mackenzie Presbyterian University, São Paulo, Brazil.

Marcelo A. Pereira-da-Silva,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Natalia Mayumi Inada,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Vanderlei Salvador Bagnato,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Please see the link here: https://stm.bookpi.org/ACPR-V7/article/view/13731

An Advanced Study on the Utility of Photodynamic Therapy in Dentistry | Chapter 4 | Highlights on Medicine and Medical Science Vol. 10

 In the discipline of dentistry, the twenty-first century has brought several significant improvements in science and technology, as well as a wide spectrum of unique treatment options available to dentists. Photodynamic therapy (PDT) is a new non-invasive treatment procedure that uses photosensitizers, a specific wavelength of light, and the production of singlet oxygen and reactive oxygen species (ROS) to kill undesired eukaryotic cells (such as oral cancers) and harmful microbes. The goal of this chapter was to summarise the history andthe benefits, drawbacks, and future prospects of PDT in several domains of dentistry (oral and maxillofacial surgery, oral medicine, endodontics, preventive dentistry, periodontology, and implantology), highlighting advantages, drawbacks, and future perspectives

Author (S) Details

Dr. Anette Stájer
Department of Periodontology, Faculty of Dentistry, University of Szeged, Tisza Lajos körút 62-64, 6720 Szeged, Hungary

Dr. Márió Gajdács
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary and Institute of Medical Microbiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary.

Dr. Zoltán Baráth
Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Tiszta Lajos körút 62-64, 6720 Szeged, Hungary.

View Book :- https://stm.bookpi.org/HMMS-V10/article/view/2252