In-vivo Photothermal and Photodynamic Therapy for Tumors Using a Theranostic Strategy Based on Graphene Oxide | Chapter 8 | Advanced Concepts in Pharmaceutical Research Vol. 7

Cancer is the second leading cause of death globally and is responsible for about 1 in 6 deaths in the world. Therefore, there is a demand to introduce novel, effective antitumor agents delivered to their specific target tissue/site to improve the efficiency of cancer diagnosis and treatment and limit the undesired systemic adverse effects caused by conventional chemotherapeutic agents. In this context, graphene oxide (GO) has garnered interest in biomedicine for cancer therapy due to its distinct physical and chemical properties.

This study describes the in vivo application of Graphene Oxide (nc-GO) nanocomposites whose surfaces have been modified with PEG-folic acid, Rhodamine B, and Indocyanine Green. In addition to displaying red fluorescence spectra of Rhodamine B acting as the fluorescent marker, in vivo experiments were performed using nc-GO to apply Photodynamic Therapy and Photothermal Therapy in the treatment of Ehrlich tumors in mice using Near-Infrared Light (808 nm 1.8 W/cm2).

This study utilized fluorescence images to analyze the tumor, aiming to achieve the highest concentration of nc-GO over time (time after intraperitoneal injection). The resulting time data was then employed to optimize the tumor treatment through PDT / PTT. The current study shows an example of the successful use of nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously In vivo fluorescence diagnostics and combined PDT-PTT effects for cancer treatments.

Author(s) Details:

María Paulina Romero,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil and Departamento de Materiales, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Ecuador.

Hilde Harb Buzzá,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Mirian Denise Stringasci,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Bianca Martins Estevão,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Cecília de Carvalho Castro e Silva,
MackGraphe, Mackenzie Presbyterian University, São Paulo, Brazil.

Marcelo A. Pereira-da-Silva,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Natalia Mayumi Inada,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Vanderlei Salvador Bagnato,
São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil.

Please see the link here: https://stm.bookpi.org/ACPR-V7/article/view/13731

Immobilization of BSA onto Graphene Oxide Synthesized from Hydrogenated Diamond-like Carbon| Chapter 1 | Progress in Chemical Science Research Vol.3

 Over the past few years, biomolecules, and Graphene oxide (GO) material studies have increased. The numerous processes for producing graphene oxide are being improved in an effort to offer safer and more efficient substitutes. Even though the Hummers method is one of the oldest, it continues to be one of the most effective ways to make graphene oxide from graphite powder or flake. In this chapter, GO has been synthesized from Hydrogenated diamond-like carbon (HDLC) which is tunable and an atomically smooth surface that can be deposited on a high-surface-area (100) wafer plate. The HDLC films were heated at a fixed temperature of 9000C for 30 min in a high vacuum of 1 × 10-6 torr and oxygenated at room temperature. This annealed HDLC (A-HDLC) was oxidized and described sequentially. FTIR confirms functional groups and Raman measurements confirm the G and D peak by Oxidation of A-HDLC. The surface morphology of BSA immobilized go, Oxidized Graphene, and A-HDLC, were studied by atomic force microscopy (AFM).

Author(s) Details:

Hari Shankar Biswas,
Department of Chemistry, Surendranath College, Kolkata- 700 009, India.

Please see the link here: https://stm.bookpi.org/PCSR-V3/article/view/7956

Study on Enhancement of Adhesion Force and Surface Conductivity of Graphene Oxide Films using Different Solvents | Chapter 6 | Recent Trends in Chemical and Material Sciences Vol. 1

 The nanotechnology approach was used to improve the adhesion force as well as the surface properties of graphene oxide (GO) films in this study. By employing a modified Hummer's process to oxidise pure graphite, GO has been created in powder form. Several types of solvents were used to deposit different films of GO nanoparticles (NPs), including distilled water, acetone, ethanol, dimethylformamide (DMF), and ethylene glycol. XRD and UV–vis absorption spectroscopy were used to investigate the structural and optical characteristics of GO films. Electrical properties, surface roughness, contact angle, adhesion force, wetting energy, and spreading coefficient were all looked into. The solvent type has an effect on the qualities of the produced films, it has been discovered. The electrical resistivity of films is strongly dependent on the solvent type, with distilled water having the lowest value. Furthermore, the adhesion force and average surface roughness (Ra) of GO films synthesised with distilled water are 143.4 mN/m and 7.83 m, respectively. These findings are linked to the agglomeration of hydrophilic cites and GO NPs on the surface of films, as well as the effects of their size on surface roughness expansion.

Author (s) Details

M. Abdelhamid Shahat
PV Unit, Solar and Space Research Department, National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Cairo, Egypt.

Ahmed Ghitas
PV Unit, Solar and Space Research Department, National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Cairo, Egypt.

F. M. El-Hossary
Physics Department, Faculty of Science, Sohag University, Sohag, Egypt.

A. M. Abd El-Rahman
Physics Department, Faculty of Science, Sohag University, Sohag, Egypt and King Abdul Aziz University, Jeddah, KSA.

Mohammed H. Fawey
Physics Department, Faculty of Science, Sohag University, Sohag, Egypt.

View Book :- https://stm.bookpi.org/RTCAMS-V1/article/view/2183