Therapeutic and Pharmacological Insights into Nardostachys jatamansi DC: Bridging Traditional Use and Modern Science | Chapter 7 | Pharmaceutical Science: New Insights and Developments Vol. 7

Background: Nardostachys jatamansi DC, commonly known as Indian spikenard, has a rich historical significance rooted in ancient texts. This widely utilised herb in traditional Chinese medicine has been historically employed in the management of various neuropsychiatric disorders.

 

Objectives: This review aims to consolidate existing knowledge on Nardostachys jatamansi (Indian spikenard), exploring its historical significance, botanical characteristics, chemical composition, and pharmacological activities to provide a comprehensive resource for researchers and clinicians.

 

Methodology: Information was gathered from Ayurvedic texts, modern scientific literature, and electronic databases including Google Scholar, ScienceDirect, Springer, and PubMed. The search included articles published up to 2025, using keywords such as "Nardostachys jatamansi," "botany of Nardostachys jatamansi," and "pharmacological activity of Nardostachys jatamansi." A systematic review of selected literature was conducted, focusing on botanical classification, taxonomy, ethnobotany, phytochemistry, and pharmacology. Data were analysed to identify traditional uses, chemical constituents, and experimentally validated pharmacological effects.

 

Results: Nardostachys jatamansi is highly regarded in Ayurvedic medicine for its diverse therapeutic properties, classified under various actions that promote health and well-being. Nardostachys jatamansi contains diverse chemical constituents, including terpenes, fatty acids, and other compounds such as jatamansone and nardostachone. Traditional uses in Ayurveda include treatments for neurological, cardiovascular, and dermatological conditions. Modern pharmacological studies support its antifungal, antibacterial, hepatoprotective, cardioprotective, hypolipidemic, antidepressant, antioxidant, neuroprotective, antiparkinson, anticonvulsant, anti-hyperglycemic, and anticancer activities.

 

Conclusion: Nardostachys jatamansi is a herb with significant therapeutic potential, supported by both traditional use and modern scientific evidence. Its diverse pharmacological activities warrant further investigation to explore clinical applications and develop novel therapeutic agents.

 

Author(s) Details

Shubham Kamble
Department of Pharmaceutics, The Royal Gondwana College of Pharmacy, Nagpur, India.

 

Bhagyashri R. Dhakate
Department of Pharmaceutics, National College of Pharmacy, Nagpur, India.

 

Kunjan Faye
Department of Pharmaceutical Chemistry, Institute of Diploma in Pharmacy (Govt. Aided), Borgaon (Meghe), Wardha, India.

 

Harsha P. Sontakke
Department of Pharmaceutical Chemistry, National College of Pharmacy, Nagpur, India.

 

Janhavi Indurkar
Department of Pharmaceutical Chemistry, Central India College of Pharmacy, Nagpur, India.

 

Meenal Watkar
Department of Pharmaceutical Quality Assurance, Central India College of Pharmacy, Nagpur, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v7/5882

Herba Sideritis: Insights from a Herbal Monograph with Particular Reference to Adaptogenic Potential in Neurodegenerative Disorders and Aging-related Cognitive Decline | Book Publisher International

Background: Greek mountain tea (GMT), Herba Sideritis (Sideritis scardica Griseb.), is traditionally used to treat the common cold and mild gastrointestinal disorders. Sideritis spp. has been characterized as a genus with more than 150 perennial species widely distributed in the Mediterranean and the Canary and Madeira Islands. GMT was adopted in 2015 in the European Union as a traditional herbal medicine. Recent studies suggest its potential efficacy for reducing the risk of age-related cognitive decline and neurodegenerative diseases, which could be associated with the common mechanisms of action.

 

Aims and Hypothesis: The aims of this monograph were: (i) to systematically update new evidence of the quality, efficacy, and safety of GMT preparations and validate their potential health benefits, and (ii) to elaborate a rationale for a mode of polyvalent pharmacological action, which is likely associated with a regulation of the neuroendocrine-immune complex (stress system).

 

Methods: Literature screening using the Pubmed database and original publications were assessed according to WHO criteria for monographs of herbal medicines.

 

Results: Sideritis scardica extracts and its ingredient phenylethyl-phenylpropanoid glycoside acteoside (AC, syn. verbascoside) exhibited cognitive improvement, stress-protective, neuroprotective, neurogenesis, anxiolytic, anti-aging, anti-inflammatory, antimicrobial, gastroprotective, glycemic, anti-obesity, antioxidant, and anti-tumor activity. According to the findings, the combination of Sideritis scardica with vitamin B may be relevant for persons solving cognitive tasks under conflict and/or noise (e.g., open-plan offices or car-driving) and support that the tested product alleviates stress-induced impairment of executive functioning (working memory, cognitive flexibility, controlled behavioral inhibition). The recent findings supported by preclinical and clinical data suggest using Herba Sideritis extracts to improve cognitive functions and mental disorders in aging.

 

 

 

Conclusion: This monograph provides systematic information on the safety, efficacy, and quality of Herba Sideritis, paving the way for its potential use in reducing the risk of age-related cognitive decline and neurodegenerative disorders. It includes details of botanical descriptions, chemical constituents, dosage recommendations, adverse effects, and interactions for health professionals, researchers, and policymakers aiding in evidence-based practices and ensuring the safe use of medicinal products. Further preclinical and clinical research is crucial to fully validate GMT's health benefits and unravel the mechanisms underlying its adaptogenic effects.

 

 

Author (s) Details

Alexander Panossian
Phytomed AB, Sjostadsvagen 6A, Lgh 1004, 59344 Vastervik, Sweden.

 

Terrence Lemerond
EuroPharma USA Inc., Green Bay, WI 54311, USA.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48119-26-1

Plant Bioactive Constituents Play a Potential Role in the Treatment of Spasticity in Multiple Sclerosis: A Review | Chapter 9 | Recent Developments in Medicine and Medical Research Vol. 14

 Multiple sclerosis (MS) is a debilitating central nervous system (CNS) illness that attacks in early adulthood. Despite various FDA-approved drugs in the United States, multiple sclerosis therapy choices are limited. The study's major focus was on plant bioactive components, which have an essential role in the treatment of spasticity in people with Multiple Sclerosis. Many patients with MS seek out herbal therapies to assist them manage their symptoms and control their disease. According to research, 70-80% of persons with MS have tried plant products or bioactive chemicals to help them with their symptoms. Patients with MS who utilise herbal medications may provide additional study opportunities. The most often used phytotherapies are diet, omega-3 fatty acids, and antioxidants. In both relapsing and progressive types of MS, bioactive plant chemicals such as flavonoids, vitamin C, lipoic acid, and vitamin D supplementation were found to be the most promising anti-inflammatory and neuroprotective agents. Polyphenols, terpenes, alkaloids, anthocyanidine glycosides, plant amines, volatile oils, and other natural substances will all have a part in the future therapy of multiple sclerosis.

Author(S) Details

G. Neelamma
Srikrupa Institute of Pharmaceutical Sciences, Siddipet, Telangana, India.

B. Nagarani
Srikrupa Institute of Pharmaceutical Sciences, Siddipet, Telangana, India.

K. Mangamma
School of Pharmaceutical Sciences and Technologies JNTU, Kakinada, Andhra Pradesh, India.

View Book:- https://stm.bookpi.org/RDMMR-V14/article/view/4988