Therapeutic Effect of Anti-Inflammatory Drugs and Vitamin C against Experimentally Induced Parkinson's Disease with Rotenone in Albino Mice | Chapter 1 | Medicine and Medical Research: New Perspectives Vol. 10

Parkinson's disease is a brain disorder that causes unintended or uncontrollable movements, such as shaking, stiffness, and difficulty with balance and coordination. Symptoms usually begin gradually and worsen over time. As the disease progresses, people may have difficulty walking and talking. The nigrostriatal pathway is a dopaminergic pathway that connects the substantia nigra with the dorsal striatum. Loss of dopamine neurons in the substantia nigra is one of the main pathological features of Parkinson's disease, leading to a marked reduction in dopamine function in this pathway.

 

Author (s) Details

 

Nagi Ali Ibrahim
Faculty of Science, Zagazig University, Zagazig, Egypt.

 

Omar Mohamed Abdel-Salam
National Research Center, Dokki, Giza, Egypt.

 

Yasser Ashry Khadrawy
National Research Center, Dokki, Giza, Egypt.

 

Amal Mohamed Hashem
Faculty of Science, Zagazig University, Zagazig, Egypt.

 

Eman Mohamed Samir
Faculty of Science, Zagazig University, Zagazig, Egypt.

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v10/9071A

Exploring the Benefits of Active Pharmaceutical Ingredients as Ionic Liquids for Indomethacin and Mebendazole | Chapter 5 | Current Innovations in Chemical and Materials Sciences Vol. 6

Some of the main challenges that the pharmaceutical industry has to face is to overcome the physicochemical problems that many drugs present due to polymorphism, low solubility, and low bioavailability. Recently, it has been shown that the combination of solid, poorly water-soluble Active Pharmaceutical Ingredients (APIs) with suitable counter-ions to give liquid forms (API-ILs) can resolve these limitations. The purpose of this study was to explore the transformation of Indomethacin and Mebendazole, two solid, poorly water-soluble APIs into new API-ILs. Their structures were selected by their pharmaceutical interest, their susceptibility of being transformed into API-ILs (either to form the cation or the anion), and their limited bioavailability, mainly due to its low solubility. The counterions were carefully chosen aiming for high biocompatibility, low toxicity and high water solubility such as those derived from DMEA, TMG, DBU, TED, p-toluensulfonic acid, glycolic acid, methanesulfonic acid and saccharine. The synthesis was carried out by direct treatment of the API with the corresponding selected acid or base. Solubility tests showed a high increase of water solubility for all the salts synthesised, especially for the API-ILs derived from indomethacin which showed a water solubility in the range of 185 and 218 mg/mL, around 75000-hold higher than free drug indomethacin.

Author(s) Details:

Emilia Tojo,
Faculty of Chemistry, University of Vigo, Marcosende, As Lagoas, 36210-Vigo, Spain.

Verónica Fernandez-Stefanuto,
Faculty of Chemistry, University of Vigo, Marcosende, As Lagoas, 36210-Vigo, Spain.

Please see the link here: https://stm.bookpi.org/CICMS-V6/article/view/13529

Determination of Anti-Inflammatory Potential of Cassia italica (Mill) Lam. EX. FW. Andrews Leaves | Chapter 08 | Current Aspects in Pharmaceutical Research and Development Vol. 3

 Because of their high therapeutic value, Cassia species have piqued the interest of phytochemical and pharmacological researchers. In animal models, the anti-inflammatory efficacy of a methanolic extract of Cassia italica leaves was examined. The extract demonstrated good anti-inflammatory efficacy at various doses, which was aided greatly by the production of oedema caused by carrageenan and formalin. These results were also comparable to Indomethacin, the study's reference drug. The findings of this study show that the methanolic extract is effective as a therapeutic agent in both acute and chronic inflammatory diseases. As a result, it's possible to conclude that Cassia italica leaf extracts have potent anti-inflammatory activities.

The goal of this study was to look into the effects of carrageenan and formalin on paw edoema in Cassia italica.

Author(S) Details

M. Sermakkani
PG and Research Center, Sri Parasakthi College for Women, Courtallam- 627 802, Tamilnadu, India.

V. Thangapandian
PG and Research Department of Botany, Kongunadu Arts and Science College, Coimbatore 641029, Tamilnadu, India.

View Book:- https://stm.bookpi.org/CAPRD-V3/article/view/4443

Curcumin, Indomethacin, and Naproxen Synergistically inhibit the Growth of Human Colorectal Cancer Cells (HT-29): Current Research | Chapter 8 | Current Topics in Medicine and Medical Research Vol. 1

The aim of this study was to investigate the effect of curcumin, indomethacin, curcumin and naproxen combination synergistically on the growth of HT-29 cells. The growth of HT-29 cells was examined by MTS cell viability assay by one to four days’ treatment with curcumin (10∼50 μM), indomethacin (250∼1,000 μM), curcumin (10∼50 μM) and naproxen (250∼1,000 μM) to 2×104 HT-29 cells/mL. The results suggested that curcumin inhibited the growth of HT-29 cells in a dose-dependent fashion. In concentration range from 500 to 1,000 μM, indomethacin inhibitied the growth of HT-29 cells in a dose-dependent fashion. To examine inhibitory administered or give of curcumin and indomethacin, curcumin and naproxen combinination on the HT-29 cell lines, we treatment with 20 μM curcumin and indomethacin (500 μM, 750 μM) combinination curcumin and naproxen (750 μM, 1,000 μM) combinination to 2×104 HT-29 cells/well. The results suggested that curcumin potentiates the inhibitory effect of indomethacin on the growth of HT-29 cell lines by shifting the dose-dependent manner. 

Author(s)  Details

Ju-Seop Kang,
Department of Pharmacology and Clinical Pharmacology Laboratory, College of Medicine, Hanyang University, Seoul 133-791, Korea. 

View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/195