Exploring the Benefits of Active Pharmaceutical Ingredients as Ionic Liquids for Indomethacin and Mebendazole | Chapter 5 | Current Innovations in Chemical and Materials Sciences Vol. 6

Some of the main challenges that the pharmaceutical industry has to face is to overcome the physicochemical problems that many drugs present due to polymorphism, low solubility, and low bioavailability. Recently, it has been shown that the combination of solid, poorly water-soluble Active Pharmaceutical Ingredients (APIs) with suitable counter-ions to give liquid forms (API-ILs) can resolve these limitations. The purpose of this study was to explore the transformation of Indomethacin and Mebendazole, two solid, poorly water-soluble APIs into new API-ILs. Their structures were selected by their pharmaceutical interest, their susceptibility of being transformed into API-ILs (either to form the cation or the anion), and their limited bioavailability, mainly due to its low solubility. The counterions were carefully chosen aiming for high biocompatibility, low toxicity and high water solubility such as those derived from DMEA, TMG, DBU, TED, p-toluensulfonic acid, glycolic acid, methanesulfonic acid and saccharine. The synthesis was carried out by direct treatment of the API with the corresponding selected acid or base. Solubility tests showed a high increase of water solubility for all the salts synthesised, especially for the API-ILs derived from indomethacin which showed a water solubility in the range of 185 and 218 mg/mL, around 75000-hold higher than free drug indomethacin.

Author(s) Details:

Emilia Tojo,
Faculty of Chemistry, University of Vigo, Marcosende, As Lagoas, 36210-Vigo, Spain.

Verónica Fernandez-Stefanuto,
Faculty of Chemistry, University of Vigo, Marcosende, As Lagoas, 36210-Vigo, Spain.

Please see the link here: https://stm.bookpi.org/CICMS-V6/article/view/13529

Improvement of the Manufacturing Process of Active Pharmaceutical Ingredients | Chapter 2 | Research and Developments in Engineering Research Vol. 7

This work aims to resolve and implement improvements in supplies integrated into result processes in pharmaceutical workshops for the production of alive pharmaceutical elements (API). In the project, studies were carried out utilizing the finite piece method (FEM) and usual structural design, to test the feasibility of the picked solutions. Then, the cost study was carried out, and the benefits and results of the new supplies were presented. It was attainable to conclude that the projected equipment illustrates advantages at an fitting, hygienic and efficient level compared to the original one, which interprets into an increase of the company’s competitiveness in the pharmaceutical advertise.

Author(s) Details:

A. C. P. Soares,
Departamento de Engenharia Mecânica, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, R. Dr. António Bernardino de Almeida, 431, 4200-072 Porto, Portugal.

R. D. S. G. Campilho,
Departamento de Engenharia Mecânica, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, R. Dr. António Bernardino de Almeida, 431, 4200-072 Porto, Portugal and INEGI – Pólo FEUP, Rua Dr. Roberto Frias, 400, 4200-465 Porto, Portugal.

M.S. Kirgiz,
Departamento de Engenharia Mecânica, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.

M. V. Kumar,
Department of Civil Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India.

R. Alzein,
Department of Civil Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India.

Please see the link here: https://stm.bookpi.org/RADER-V7/article/view/11702