Evaluating the Antioxidant Potential and High Performance Thin Layer Chromatography Profiling of Siddha Formulation Veppampoo Mathirai | Chapter 7 | Medical Science: Trends and Innovations Vol. 7

In today’s world, herbals play a significant role in boosting immunity and preventing diseases. In some parts of the world, they are the primary required materials for healthcare system. In herbal formulation, some plants or specific combinations of herbs may act as antioxidants by exerting superoxide scavenging activity or by increasing superoxide dismutase activity in various tissue sites. Plant antioxidants play a vital role in the battle against cellular damage and disease. The present study aimed to study the antioxidant potential and basic TLC, HPTLC fingerprinting profile of poly herbal Siddha formulation Veppampoo Mathirai used for hypertension to regulate blood pressure in the Siddha system of medicine. The antioxidant action was measured by ABTS free radical scavenging assay, lipid peroxidation and nitric oxide scavenging measure. The common modern techniques that help to evaluate the quality control of complex herbal medicine are thin layer chromatography (TLC) and High performance thin layer chromatography (HPTLC). World Health Organization also indicated the above as a valuable tool to ensure the quality of medicinal plant products. Analysis of TLC was done by silica gel 60F254, 7X6 cm (Merck) and HPTLC by CAMAG Twin trough chambers. All outcomes of the sample were communicated as mean ± standard deviation compared with control. The study revealed the presence of a prominent peak at 366 nm in TLC analysis and twelve prominent peaks in HPTLC analysis with Retention factor (Rf) value ranging from 0.02 to 0.86. ABTS scavenging assay, lipid peroxidation and nitric oxide scavenging showed EC₅₀ values of aqueous extract of Veppampoo mathirai at 55.32 μg/mL, 51.3 μg/mL and 51.31 μg/mL, separately. The above results revealed that the aqueous extract of Veppampoo mathirai has solid antioxidant possibilities and is also a good source of natural antioxidants. It is concluded that Siddha formulation Veppampoo mathirai is a good source of natural antioxidants that can be utilized for age-related diseases like blood pressure as therapeutic.

 

Author (s) Details

S M Chitra
Department of Post Graduate Maruthuvam, Government Siddha Medical College, Arumbakkam, Chennai-106, Tamil Nadu, India.

 

N Anbu
Department of Post Graduate Maruthuvam, Government Siddha Medical College, Arumbakkam, Chennai-106, Tamil Nadu, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v7/4442

Ancestral Beauty Secrets in Siddha Sytem of Medicine: A Review | Chapter 2 | Current Overview on Pharmaceutical Science Vol. 9

 The real record of cosmetic usage maybe seen in old people and civilization's experienced concerns, such as protection from two together UV rays A and B; hierarchic social categories; or allure delegates of beauty. The ancient use of advantage products is trusted to have originated in India. Natural cosmetics concern preparations of plants, flowers, and fruits from the treasure of the Siddha scheme of unparalleled money beautify and take care of their skin and their eyebrow. In this present study, cosmetics applications are reviewed below to understand the exertion taken apiece 'Siddhars' to evolve the Science of cosmetics. Natural additives originally ancestral advantage rituals to a degree skin tonics, sunscreen, skin lightening and exfoliating cancel, dry skin, pimple cure, lip ointment, cure for dandruff, fur care product, dental care, depilatory, breast builders, cure for lice and nits and anti-slumping herbs have been argued as per the classical references and accessible scientific validations in Siddha system. It is decided that cosmetic use was created by the ancient Siddha order and was practiced using natural resources found on two together land and sea.

Author(s) Details:

R. Devaki,
Postgraduate Department of Gunapadam (Pharmacology), Government Siddha Medical College, Arumbakkam, Chennai, Tamil Nadu, India.

R. Kalpana,
Postgraduate Department of Gunapadam (Pharmacology), Government Siddha Medical College, Arumbakkam, Chennai, Tamil Nadu, India.

A. Ganesan,
Postgraduate Department of Gunapadam (Pharmacology), Government Siddha Medical College, Arumbakkam, Chennai, Tamil Nadu, India.

V. Velpandian,
Postgraduate Department of Gunapadam (Pharmacology), Government Siddha Medical College, Arumbakkam, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/COPS-V9/article/view/10167

Neuroprotective Activity of Siddha Herbo-Mineral Formulation Muthu Parpam through Acetylcholine Esterase Enzyme Inhibition Assay for the Treatment of Alzheimer Disease| Chapter 9 | Current Overview on Pharmaceutical Science Vol. 4

 Alzheimer's disease (AD) is a growing neurodegenerative condition evidenced by meaningful cognitive dysfunction.  The state of intelligent impairment is worsend a situation by increased levels of the catalyst acetylcholinesterase (AChE), which is important in the hydrolysis of the neurotransmitter acetylcholine (ACh). Siddha system is an old traditional method of medicine that treats many never-ending ailments and affecting animate nerve organs disorders. Muthu parpam is one of the herbo-marine Siddha drugs namely indicated for neurocognitive dysfunction and insane illness. The basic goal concerning this present study was to judge the acetylcholine esterase (AChE) inhibition of Muthu parpam.AChE endeavor was evaluated utilizing a modified 96-well microplate assay established Ellman’s method. Physostigmine (5, 10, 20, and 40 µg/ml) was secondhand as the positive control.According to the verdicts of this study, the test drug Muthu Parpam was persuasive in inhibiting the AChE substance causing chemicals to split into simpler substances at the specified aggregation in a dose-weak manner. Maximum allotment inhibition of about 71.68% was noticed at 500µg/ml when compared to that of the Physostigmine, a popular AChE inhibitor accompanying a maximum inhibition of 84.87% at the aggregation of 40µg/ml.As a result, this preliminary screening has illustrated the efficacy of Muthu parpam in the management of Alzheimer disease by way of AChE inhibition potential.

Author(s) Details:

N. Sabari Girija,
National Institute of Siddha, Tambaram Sanatorium, Chennai – 600047, Tamilnadu, India.

P. Shanmugapriya,
National Institute of Siddha, Tambaram Sanatorium, Chennai – 600047, Tamilnadu, India.

Please see the link here: https://stm.bookpi.org/COPS-V4/article/view/9366

In silico Computational Analysis of Siddha Formulation Veppampoo Mathirai against Hypertension| Chapter 4 | Current Overview on Disease and Health Research Vol. 11

The most of population are impressed accompanying hypertension (HTN), ultimate accepted non-communicable ailment in the realm. Despite the extensive chance of up-to-date drugs, crowd still express interest in utilizing established cure systems like Siddha to treat unacceptable reactions. Through in silico computational study, Veppampoo mathirai, a polyherbal Siddha expression, was checked for allure potential affect HTN. Through a research review, the phytochemicals in the expression were recognized, chosen out, and assembled. The AutoDock tool tale 4 was used to complete activity a microscopic anchoring analysis. The mark something which incites activity angiotensin-adapting something which incites activity (ACE) was used to recognize the lead compounds, that were then distinguished to common captopril.  Among the phytoprinciples analysed, Nimbiol and Gallic acid had ten interplays, inasmuch as Piperic acid, Peperine, and Nimbolide had nine interplays that are above the standard Captopril. According to the results of the current inspection, the expression Veppampoo mathirai can have potential binding effect against the ACE target something which incites activity, that lowers ancestry pressure.

Author(s) Details:

S. M. Chitra,
Department of Postgraduate Maruthuvam, Government Siddha Medical College, Arumbakkam, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/CODHR-V11/article/view/9287

Medicinal Effects of Mollugo cerviana - A Brief Review | Chapter 05 | Current Aspects in Pharmaceutical Research and Development Vol. 7

 Humankind has been diagnosed with a wide spectrum of infections and ailments in recent years. Allopathic medications, on the other hand, are in short supply. In the last several years, we've gained a better understanding of illness aetiology and bioactive components, which has aided medication development. Plant extracts are used to strengthen the immune system in this circumstance, based on Ayurvedic and Siddha understanding. Mollugo cerviana is a phytochemical-dense herb found in India (commonly known as thread stem carpet weed). Fever, stomachaches, jaundice, gout, and rheumatism are all treated with this plant. It's also used to help with vaginal discharge after a baby is born. Antimicrobial, anti-inflammatory, antioxidant, and spermicidal activities are all present in the plant. The plant has a high hepatoprotective efficacy and photoprotective capacity due to the presence of phytochemicals such as carbohydrates, saponins, tannins, terpenoids, flavonoids, steroids, phenols, proteins, and alkaloids. In a nutshell, the majority of medical applications are due to plant extracts. This review is a collection of studies on Mollugo cerviana and its bioactivities that are useful.

Author(S) Details

A. A. Aglin
Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi, Tamilnadu, India.

View Book:- https://stm.bookpi.org/CAPRD-V7/article/view/5413