Natural Products in Drug Discovery | Chapter 7 | Natural Products Chemistry: From Discovery to Applications, Edition 1

Natural goods have long been a potent source of medications since they include several structurally distinct bioactive compounds with medicinal qualities. A significant proportion of effective pharmaceuticals, such as antibiotics and anticancer agents, originate from natural products sourced from plants, microorganisms, and marine organisms. This abstract emphasizes that natural products remain a valuable source of lead compounds, as their unique chemical structures can inform the development of enhanced synthetic alternatives. Extraction, isolation, and synthesis techniques continue to evolve, while synthetic biology is advancing, rendering natural products essential for the discovery of novel pharmaceuticals.

 

Author (s) Details

Deepanshu Ran
Department of Microbiology, School of Lifesciences, Sardar Bhagwan Singh University, Balawala, Dehradun-248161, Uttarakhand, India.

 

Keshari Nandan
Department of Chemistry, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttarakhand, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48388-70-4/CH7

Comprehensive Review on Drug-Loaded Niosomes: A Promising Nanocarrier-based System | Chapter 2 | Pharmaceutical Research: Recent Advances and Trends Vol. 10

Vesicular drug delivery systems, niosomes are currently innovative delivery systems that encapsulate hydrophilic and hydrophobic drugs into the core and the bilayer of these niosomes. Niosomes are composed of non-ionic surfactants and differ from traditional liposomes by having chemical stability and smaller drug leakage. Targeted drug delivery with enhanced therapeutic efficiency is achieved, as well as a reduction in side effects and increased drug presence at the target site. Preparation of niosomes, their types, advantages and drawbacks are discussed in this review.

 

Author (s) Details

 

V. Himabindu
Department of Pharmaceutics, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v10/3271

Topical Gel Loaded with Fluconazole Niosomes: Formulation and Evaluation Study | Chapter 6 | Challenges and Advances in Pharmaceutical Research Vol. 5

 

 Designing and evaluating topical gel-loaded fluconazole niosomes is the aim of the project. Fluconazole, a macrolide antibiotic, is used to treat a number of delicate bacteria. Niosomes can boost a drug's skin penetration and lengthen its duration in the stratum corneum and epidermis while decreasing its absorption throughout the body. Because they may change pharmacokinetics and bioavailability as well as reduce toxicity, niosomes play a significant role in the administration of medications.

It was determined during the study that the sample is a pure substance. Fluconazole (pure medication) acquired Fourier transform infrared (FTIR 8400s, Shimadzu Japan) spectra were examined. The procedure of potassium bromide discs was utilised.

improved formulations With vesicle diameters of 845.6 nm and 164.2 nm, respectively, and zeta potentials of -10.2 mV and -46.4 mV, the formulation for FNS5 and FNT4 produced with Span-60 and Tween-60 is stable. The improved niosomes were then thoroughly assessed for zeta potential and vesicle size after being added to gels made of carbopol 934 and guar gum.

According to the study, drug retention, penetration, and release times were all prolonged when drugs were trapped in niosomes.

 

Author(s) Details:

Gajjala Sravan,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

K. Latha,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

R. Padmavathi,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

Maimuna Fatima,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

C. V. Sai Sravani,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

M. Saritha,
Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh-530049, India.

Please see the link here: https://stm.bookpi.org/CAPR-V5/article/view/7774