The present study highlights the positive effect of elevated p-cresol levels in the brain through the experiment on rats. It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders, including Autism, Epilepsy, Parkinson's, Alzheimer's, depression, etc. However, contrary to existing consensus, it was recently found that lowering the level of p-cresol in the brain of rats leads to a decrease in cognitive activity and, significantly affects the social projection of cognitive activity. The aim of the study is to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test was employed to assess learning capabilities. The results, with a high confidence level, for the first time, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group. This research initiates a new understanding of the relationship between gut microbiota and the brain, highlighting the beneficial role of substances produced by gut microbiota in brain function.
Author (s) Details
Gigi Tevzadze
4D Research Institute, Ilia State University, Tbilisi, 0162, Georgia.
Zaal Kikvidze
Institute of Ecology, Institute of Botany, Ilia State University, Tbilisi,
0162, Georgia.
Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v4/2885
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