A fungal infection of the nail, onychomycosis is also referred to as dermatophytid onychomycosis or tinea unicum. The pathogens that cause onychomycosis are nondermatophytic molds, dermatophytes, and Candida. This effort has created a medicated antifungal nail lacquer using miconazole nitrate. The study's goal was to cut down on the frequency of administration by providing a sustained release of miconazole nitrate over a 48-hour period. This was anticipated to increase both patient compliance and clinical efficacy. Through straightforward mixing, the nail lacquer formulation was created, and its non-volatile content, gloss, smoothness of flow, drug diffusion tests, drug content estimation, and anti-microbial research were all examined.
The nail lacquer made with 2% Miconazole nitrate, 6%
Nitrocellulose, 1% Ethylcellulose, 15% Acetone, 10% Iso Propyl Alcohol, 10% Di
Butyl Palathee, and 5% Ethyl Acetate showed the best non-volatile content, drug
release, drug content estimation, and zone of inhibition out of all the
formulations. A complete release of 98.12% was noted, and the medication
release could be prolonged for up to 48 hours. Drug and excipient compatibility
was demonstrated by FTIR tests. Following ICH recommendations, an accelerated
stability investigation of the chosen optimized formulation, F4, was conducted
for one month at 40±20C. The results showed no discernible change from the
baseline features. These systems are thought to be simple and safe to develop
and use. Thus, it is possible that antifungal nail lacquer is one of the
innovative dosage forms that have the potential to completely transform the
pharmaceutical and medical industries.
Author (s) Details
Devapangu Chinna Babu
Department of Pharmaceutics, Anurag Pharmacy College, Kodad (M), Suryapet(D),
Telangana State, 508 206, India.
Please see the book here:- https://doi.org/10.9734/bpi/psnid/v2/3829
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