This chapter presents an overview of fine-needle aspiration
cytology (FNAC) and its role in the evaluation of breast cancer biomarkers.
Breast cancer is the most common cancer among women, accounting for 22% of all
female cancers. In breast cancer, the overexpression of human epidermal growth
factor receptor-2 (HER-2/neu) is a prognostic marker indicated for
stratification of patients for HER-2/neu targeted therapies. The steroid
hormonal receptors for estrogen receptor (ER) and progesterone receptor (PR) are
markers with prognostic value in early-stage cancer of the breast and ER is
predictive for response to hormonal therapies. Fine-needle aspiration cytology
(FNAC), can provide enough cellular samples and evaluation of HER2, ER and PR
expression patterns has relevant clinical application because the sample can be
collected before surgery and help plan the management of breast cancer
patients. Evaluation of HER2, ER and PR status in cytology samples has a lot of
clinical relevance since the sample can be obtained prior to surgery and help
plan management of patients with inoperable breast carcinoma. Previous studies
have reported that immunocytochemistry performed on cell block is a feasible
method for evaluation of ER, PR and HER-2/neu status in breast cancer,
especially when the cellblock has adequate tumor cells.
Author(s)details:-
Mutinda C. Kyama
Department of Medical Laboratory Sciences, School of Biomedical Sciences,
College of Health Sciences, Jomo Kenyatta University of Agriculture &
Technology, P.O. Box 62000-00200, City Square, Nairobi, Kenya.
Please See the book
here :- https://doi.org/10.9734/bpi/mria/v3/8248A
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