Post Transcriptional Gene Regulation in Breast Cancer | Chapter 25 | Socio-Scientific Interaction in Diabetes and Cancer and Its Management

 Post-transcriptional gene regulation plays an important role in the development and progression of breast cancer. It occurs after the transcription of DNA into RNA but before the synthesis of functional proteins. Breast cancer is the most common and lethal cancer that affects women worldwide. Several mechanisms involved in post-transcription are RNA binding proteins (RBP), microRNA (miRNA), alternative splicing, RNA editing, and modulation of mRNA stability. They are dysregulated in breast cancer contributing to the cell proliferation and metastasis in breast cancer. Aberrant splicing events are involved in breast cancer progression and therapeutic resistance. This chapter is an overview of post-transcriptional gene regulation and its role in breast cancer.

Author(s) Details:

Shivani Mishra,
Gene Expression and Signaling Laboratory, Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India.

Saumya Jaiswal,
Gene Expression and Signaling Laboratory, Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India.

Smriti Shreya,
Gene Expression and Signaling Laboratory, Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India.

Buddhi Prakash Jain,
Gene Expression and Signaling Laboratory, Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India.

Please see the link here: https://stm.bookpi.org/SSIDCIM/article/view/12743