Spectroscopic Methods for Analysing Herbal Medicine and their Roles in Healthcare |Chapter 1 | Pharmaceutical Science: New Insights and Developments Vol. 10

 

Background: Spectroscopic methods are very fundamental, convenient, cost-effective and available equipment settings in both industry and laboratory to analyse a range of products, including food, medicines, cosmetics and herbal products. Herbal drugs, that is, plant-derived products, have been used in the healthcare system from ancient times. There are different types of spectroscopic methods, among which ultraviolet and visible spectroscopy, infrared spectroscopy, atomic absorption spectroscopy, Mass spectroscopy, Fluorescence spectroscopy and Nuclear magnetic resonance spectroscopy are widely used for analysing herbal drugs.

 

Materials and Methods: PubMed, Research Gate, Google Scholar and other search engines, including Artificial intelligence tools, have been searched to find suitable literature to find relevant research works. The keywords “Spectroscopy”, “Herbal medicines”, “UV-VIS spectroscopy”, “Analysis”, “Infra-Red spectroscopy”, “Raman spectroscopy”, “Atomic absorption spectroscopy”, “Mass spectroscopy”, “Nuclear magnetic resonance spectroscopy”, “Analysis of herbs and phytoconstituents” etc. have been applied to find expected research articles and collect information on various aspects of spectroscopic methods for analysing herbal medicine and their roles in healthcare.

 

Results: After a thorough study of a lot of published articles, standard textbooks and related literature, we found some spectroscopic methods which are suitable for the analysis of herbal drugs. Some of these methods are - ultraviolet spectroscopy, infrared and Fourier Transform Infra-red spectroscopy, Raman spectroscopy, atomic absorption spectroscopy, fluorescence spectroscopy, Nuclear magnetic resonance spectroscopy and mass spectroscopy. Several tandem systems integrate spectroscopic and chromatographic techniques. Prominent examples include gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). These methods are highly suitable, specific, sensitive, and readily amenable to validation.

 

Conclusion: Spectroscopic methods provide a reliable and cost-effective approach for evaluating phytochemical potency and ensuring the quality of herbal preparations, making them essential tools in routine laboratory analysis.

 

 

Author(s) Details

Sabiha Ferdowsy Koly
Department of Pharmacy, Southeast University, Tejgaon-1215, Dhaka, Bangladesh.

 

Md. Shah Amran
Department of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Bashudhara, Dhaka-1229, Bangladesh.

 

Please see the book here :- https://doi.org/10.9734/bpi/psnid/v10/6660

Role of Medicinal Plants in the Treatment of Diabetes Mellitus | Chapter 27 | Socio-Scientific Interaction in Diabetes and Cancer and Its Management

 Medicinal plants play a significant role in the treatment of diabetes mellitus which is a serious metabolic disorder. Traditional plants are reported to have significant anti-diabetic properties with no harmful side effects. They are rich sources of anti-diabetic compounds such as flavonoids, alkaloids, phenolics, and tannins that improve the efficiency of pancreatic tissues by increasing insulin secretion or decreasing the intestinal absorption of glucose. However, these over-the-counter drugs are expensive and associated with several complications. Herbal medicines are gaining importance as they are cost-effective and also display improved therapeutic effects with lesser side effects. The present analysis includes available medicinal plants used for treating diabetes complications. This study provides useful information about the different medicinal plants for treating diabetes-associated complications. The aim of the study is to categorize and summarize the available information on medicinal plants with anti-diabetic properties and suggest outlooks for future research.

Author(s) Details:

Sanjeev Kumar Vidyarthi,
Department of Botany, Dr. L.K.V.D College, Tajpur, Samastipur- 848130, India.

Kumari Sushma Saroj,
Department of Zoology, Dr. L.K.V.D College, Tajpur, Samastipur- 848130, India.

Hari Mohan Prasad Singh,
Department of Chemistry, Dr. L.K.V.D College, Tajpur, Samastipur- 848130, India.

Please see the link here: https://stm.bookpi.org/SSIDCIM/article/view/12745

Modulatory Effects Atractylodes lancea on CYP1A2 and CYP3A1, Pharmacokinetics and Biodistribution | Chapter 7 | Novel Aspects on Pharmaceutical Research Vol. 4

 The study proposed to investigate the modulatory belongings of Atractylodes lancea (Thunb.) DC. (A. lancea: AL), a promising candidate for medicating cholangiocarcinoma, on cytochrome P450 (CYP450) 1A2 AND 3A1, pharmacokinetics and biodistribution in animals. Herbal cure is becoming more used to enhance general strength and well-being, and it is still used alone for particular health questions or with up-to-date medicine. To investigate CYP1A2 and CYP3A1 modulatory actions following long-term uncovering, rats of both genders taken oral doses of the formulated AL at 1,000 (depressed dose), 3,000 (medium prescription), and 5,000 (high lot) mg/kg body weight regularly for 12 months. For short-term belongings, male rats were orally administered the planned AL at 5,000 mg/kg body burden daily for 1, 7, 14 and 21 days. The pharmacokinetic study was administered in male rats after administration of the planned AL at the dose of 5,000 mg/kg bulk weight constantly for nine months. Due to the poor solubility of ATD, which power affect the bioavailability of the compound, the bioavailability and biodistribution of the polylactic-co-glycolic acid nanoparticles of ATD (ATD-PLGA-NPs) were examined in mouse liver utilizing matrix-assisted ray of light desorption ionization-imaging bulk spectrometer (MALDI-IMS). The biodistribution study was conducted in a male rodent receiving ATD-PLGA-NPs at the equivalent dose to ATD of 100 mg/kg bulk weight. The extreme dose of formulated AL created an inducing effect on CYP1A2 but an inhibitory effect on CYP3A1 ventures in male rats. The low prescription, however, did not prevent or induce the projects of both enzymes in male and female rats. The current examination of CYP450 modulatory activities was part of a big study to evaluate never-ending toxicity (long-term uncovering) and to identify the metabolic pathway (temporary exposure) of the planned AL. ATD reached a maximum plasma aggregation (Cmax) of 359.73 ng/mL at 3 h (tmax). Mean residence opportunity (MRT) and terminal phase removal half-life (t1/2z) were 3.03 and 0.56 h, respectively. The extent of biodistribution of ATD in rodent livers taking ATD-PLGA-NPs was 5-fold of that receiving free ATD. In order to avoid potential herb-drug interactions afterwards prolonged use, dispassionate use of low-shot AL should be taken into concern. ATD-PLGA-NPs is a possible drug transmittal system for the treatment of cholangiocarcinoma.

Author(s) Details:

Kesara Na-Bangchang,
Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand, Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University (Rangsit Campus), Pathumthani, Thailand and Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Pathumthani, Thailand.

Tullayakorn Plengsuriyakarn,
Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University (Rangsit Campus), Pathumthani, Thailand.

Please see the link here: https://stm.bookpi.org/NAPR-V4/article/view/11005

Study about Toxicity of Mentha x piperita L. | Chapter 3 | New Innovations in Chemistry and Biochemistry Vol.8

  While Mentha x piperita L. is a common herb used to make tisanes in northern Portugal, there is little information on its potential toxicity. The purpose of this study was to see how hazardous the aqueous extract was to Tetrahymena pyriformis' physiology, morphology, and biochemistry. Mint extract has a dose-dependent effect on generation time and growth. It was also discovered that the morphometric characteristics of T. pyriformis cells were changed. Mint extracts demonstrated a dose-dependent effect in the MTT experiment. Mentha x piperita L leaves extract should only be used with caution.

Author(s) Details:

José Manuel Neves,
CIIMAR (Centro Interdisciplinar de Investigação Marinha e Ambiental), Portugal and UFP (Universidade Fernando Pessoa), Portugal and CBA (Azores Biotechnology Center), Portugal.

Please see the link here: https://stm.bookpi.org/NICB-V8/article/view/6282