Diabetic cystopathy, a complication of diabetes affecting the
bladder, is mainly characterized by reduced contractility of the detrusor and
increased post-voiding residual volume, which is induced by the reduction of
the interstitial cells of Cajal. Previous studies have shown that interstitial
cells of Cajal (ICCs) in the detrusor have pace-making ability, which is
responsible for the contraction of the detrusor. Taken together, increased SCL expression in DCP patients may
initiate a cascade of events, resulting in increased c-KIT activity, thus leading to the rescue of bladder function. The
c-KIT protein is a specific marker of
the interstitial cells of Cajal and the product of a c-KIT proto-oncogene. The interstitial cells of Cajal in a high
glucose medium express less c-KIT
mRNA and protein. SCL gene serves to
assemble SCL complexes on the c-KIT promoter, sustaining c-KIT transcription. Proper transduction
of exogenous SCL genetic material,
increases c-KIT expression and leads
to synthesis of the functional SCL
protein. Intravesical, lentiviral vector-mediated gene transfer has been shown
efficacious and safe. Therefore, proper intravesical transfer of RNA encoding SCL to the interstitial cells of Cajal
may enhance c-KIT transcription and
activity in the interstitial cells of Cajal of diabetic bladders, which may
improve bladder activity. Therefore, further studies may explore this treatment
strategy in detail, not only for diabetic cystopathy but also for other
clinical problems, which can ameliorate the quality of life of the patients,
and seems therefore valuable.
Author
(s) Details
Yan Chen
Department of Urology, The First Affiliated Hospital of Zhengzhou
University, Zhengzhou, 450052, China.
Jin Sheng Li
Department of General Surgery, Zhengzhou University Affiliated Children's
Hospital, Zhengzhou, 450053, China.
Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v11/2592
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