Aims: This chapter aims to provide a comprehensive overview of the
anatomy, physiology, and histology of the cervix and anal canal in women. It
further explores the role of the Human Papilloma Virus (HPV) in the
pathogenesis of cervical and anal carcinogenesis, emphasizing the epidemiology,
oncogenic mechanisms, and associated lesions.
Study Design: The chapter is structured as a detailed review of
current literature, integrating anatomical, physiological, and pathological
aspects with epidemiological data on HPV-related cancers. Key areas include the
anatomy and histology of the cervix and anal canal, HPV virology, the
epidemiology of HPV-related cancers, and the mechanisms of HPV-induced
oncogenesis.
Place and Duration of Study: The literature review covers studies
published globally, focusing on research from the last two decades, with
particular attention to studies from 2000 to 2024.
Results: The findings highlight the significant impact of HPV on
cervical and anal cancer development. The chapter outlines the progression from
HPV infection to carcinogenesis, identifying the critical role of specific HPV
strains. It also discusses the screening and vaccination strategies currently
in place to prevent HPV-related lesions and their effectiveness in reducing
cancer incidence.
Conclusion: HPV plays a central role in the development of
cervical and anal cancers in women. Understanding the anatomical and
physiological aspects of the cervix and anal canal, along with the
pathophysiology of HPV, is crucial for developing effective prevention and
treatment strategies. The chapter concludes with recommendations for improving
screening and vaccination programs to reduce the burden of HPV-related cancers.
Author (s) Details
Teymur Bornaun
Department of Obstetrics and Gynecology, Istanbul University Health
Sciences, Istanbul, Bagcilar Training and Research Hospital, Istanbul 34200,
Turkey.
Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v11/2514
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