1,3,4-thiadazoles have become an important class of heterocycles and a great interest of researches because of their broad types of biological activity. The 1,3,4-thiadiazole ring's exceptional flexibility and wide range of therapeutic activity have made it an intriguing pharmacophore. This study clarifies the inherent characteristics of this five-membered heterocycle, emphasizing its polar and aromatic nature as well as its adaptability to changes that optimise its biological effect. The broad spectrum of pharmacological action that 1,3,4-thiadiazole compounds display, including antimicrobial, antifungal, antiviral, anticancer, and anti-inflammatory effects was discussed. In this study, the maximal electroshock (MES) model was employed to evaluate the anticonvulsant potential of thiadiazole-based compounds, while their antiviral efficacy was assessed using the Tobacco Mosaic Virus (TMV) model. Numerous studies have also demonstrated the anticancer, anti-inflammatory, antifungal, antiviral, antibacterial, anticonvulsant, and antiparasitic properties of molecules having thiadiazole rings. Additionally, this study highlights the enormous potential for developing targeted medicines with improved effectiveness and selectivity and examines the intriguing possibilities of this flexible framework in the next drug discovery and development. Overall, this analysis highlights how important 1,3,4-thiadiazole is as a flexible pharmacophore that has the potential to completely change the field of medicine.
Author
(s) Details
P. Indhumathy
Department of Pharmaceutical Chemistry and Analysis, School of
Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced
Studies, Chennai, Tamil Nadu, India.
R. Gandhimathi
Department of Pharmaceutical Chemistry and Analysis, School of
Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced
Studies, Chennai, Tamil Nadu, India.
Please see the book here:- https://doi.org/10.9734/bpi/psnid/v5/4810
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