Background: Several novel technologies for oral drug delivery have recently become available to address the physicochemical and pharmacokinetic characteristics of drugs, while improving patient compliance. The basic disadvantage of conventional tablets is the high first-pass metabolism, which can be overcome by designing fast dissolving tablets (FDT).
Objective: The limited oral bioavailability of Levocetirizine
Dihydrochloride, primarily due to its extensive first-pass metabolism,
necessitated the development of fast-dissolving tablets that rapidly
disintegrate in the oral cavity.
Methods: Fast-dissolving tablets containing 5 mg of Levocetirizine
Dihydrochloride were formulated using the direct compression method with three
synthetic super disintegrants in varying concentrations. Tablet thickness,
Hardness Test, Friability Test, etc., were done for evaluation. Three tablets
from each formulation were randomly selected, and in vitro dispersion time was
performed. The formulation development
was primarily influenced by the type and concentration of polymers and the
physicochemical properties of the drug.
Results: FTIR analysis confirmed the compatibility of the polymers
with the drug. Various evaluation parameters, including thickness, weight
variation, hardness, friability, in vitro dispersion time, wetting time, water
absorption ratio, drug content uniformity, and in vitro drug release, were
assessed. The optimized formulation (PF-9) exhibited an in vitro drug release
of 99.81% within 10 minutes, with an in vitro dispersion time of just 1 second.
Conclusion: Among all developed formulations, the one containing
2.5% croscarmellose sodium (PF-9) was identified as the most effective,
demonstrating superior disintegration and drug release characteristics for Levocetirizine
Dihydrochloride tablets.
Author
(s) Details
Y. Ismail
Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of
Science & Technology, GST Road, Vandalur, Chennai, Tamil Nadu, India.
Voleti Vijaya Kumar
School of Pharmacy, Sathyabama Institute of Science and Technology, Jeppiar
Nagar, OMR Road, Chennai, Tamil Nadu, India.
Please see the book here:- https://doi.org/10.9734/bpi/psnid/v5/4878
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