The present study provides the various methods for insulting
ARDS in animal model, along with advantage and disadvantage of each method.
Acute Respiratory Distress Syndrome (ARDS) is an acute inflammatory lung
injury. There is an immune-cell-mediated decline of the alveolar
epithelial-interstitial-endothelial complex walls in the exudative phase,
permitting plasma, plasma proteins, and cellular content into successively
flood the interstitium and airspace. ARDS occurs when there is disruption in
the alveolar-capillary barrier followed by the deposition of protein rich fluid
inside the alveoli of the lungs. Less oxygen reaches the bloodstream as a
result of this protein-rich fluid, which prevents the lungs from filling with
enough air. As a result, the organs lose some of the oxygen necessary for
normal operation. Aspiration of stomach contents, pneumonia, sepsis, and severe
trauma are among the several clinical conditions linked to the onset of ARDS.
The various clinical disorders that are associated with the development of ARDS
include sepsis, pneumonia, aspiration of gastric contents, and major trauma.
Human ARDS is not caused by any single event and hence here is no such existing
animal model that would completely mimic Human ARDS.
Author(s)details:-
Mr. Subham
Kumar Panda
Department of Toxicology, Vipragen Biosciences Private Limited, Mysuru,
Karnataka, India.
Dr. V. G.
S. Sharma
Animal Testing Laboratory, Bharat Serums and Vaccines Limited, Ambernath,
Mumbai, India.
Prof. (Dr.)
B. Ray
Department of Pharmacology, College of Pharmaceutical Sciences, Puri,
Odisha, India.
Please See
the book here :- https://doi.org/10.9734/bpi/ibs/v5/3621G
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