This member primarily focuses on fabrication and review of luliconazole based 2T-SLN coagulate for the amelioration of vulvovaginal candidiasis. Vulvovaginal candidiasis (VVC), is an exceedingly accepted mucosal infection of the lower female generative tract, caused mainly by the various opportunistic fungus Candida albicans. A appendage of the normal human microbiota, C. albicans usually colonizes the vaginal lumen asymptomatically. Fungal resistance and infection frequency are major questions with the existing situation regimens for VVC, that compromises the therapeutic efficacy of antifungal cures and results in protracted situation and low patient compliance. The gist of the present research was the lie and investigation of 2 T- SLN (solid lipid nanoparticles) coagulate carrying luliconazole for the improvement of VVC. ‘2T’ symbolizes transvaginal and thermosensitive attributes of the present expression. The optimized SLNs allowed a particle size, polydispersity index and entanglement efficiency of 62.18 nm, 0.263 and 81.5% individually. To formulate the 2 T-gel, the definitive SLNs were loaded into Carbopol 971P-NF and Triethanolamine-located gel. The 2 T-SLN gel was raise to be surely spreadable and homogenous with mean extrudability (15 ± 0.4 g/cm2), viscosity (696.42 ± 2.34 Pa•s) and %drug content (93.24 ± 0.73%) principles. The pH of the prepared 2 T-SLN coagulate (4.5 ± 0.5) was in concordance with the vaginal pH (usual conditions). For in-vitro description of an optimized 2 T-SLN gel, the release movement and anticandidal activity were evaluated which offers a %cumulative drug release of 62 ± 0.5% in 72 h and 37.3 ± 1.5 mm district of inhibition in 48 h. The developed 2 T-SLN gel was found expected stable at range temperature for two months without some visible non-regularity, cracking, or breaking. It also exhibits a skin-companionable profile accompanying no noticeable symptoms of erythema or oedema. Finally, the current research serves as a new therapeutic outlook in assessing the activity of luliconazole for vaginal drug transfer using a 2 T-SLN coagulate system.
Author(s) Details:
Salma Firdaus,
Department
of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia
Hamdard, New Delhi 110062, India.
Nazia
Hassan,
Department
of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia
Hamdard, New Delhi 110062, India.
Mohd. Aamir Mirza,
Department of Pharmaceutics, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi 110062, India.
Tabasum Ara,
Department of Pharmaceutical Sciences, University of Kashmir,
J&K, India.
Hamed A. El-Serehy,
Department
of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi
Arabia.
Fahad
A. Al-Misned,
Department
of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi
Arabia.
Zeenat Iqbal,
Department of Pharmaceutics, School of Pharmaceutical Education and
Research, Jamia Hamdard, New Delhi 110062, India.
Please see the link here: https://stm.bookpi.org/ARBS-V7/article/view/12895
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