Background:
Obesity is a risk factor for cancer development and is associated with poor prognosis
in multiple tumor types. There is emerging evidence of a strong association
between obesity and gastrointestinal cancer. The molecular mechanism underlying
gastric cancer invasion and metastasis is still poorly understood. Problem of
disseminated tumor cells (DTCs) in gastric cancer remains to be relevant for
clinics and less is known concerning this problem for patients with
obesity. Aim: This study was aimed to
evaluate how incidence of DTCs in bone marrow is conditioned by excess of
adipocites in tumor microenvironment of patients with gastric cancer and
obesity. Results: There was not found the associations between availability of
DTCs in BM as well CXCR4positive cells in tumor and body mass index (BMI) but
incidence of DTC in BM was associated with high density of cancer-associated
adipocytes (CAAs) as well with high number of CXCR4-positive cells in tumor of
patients with BMI<25 and BMI>25<30 but it was not true for patients
with BMI>30 where frequency of DTCs finding in BM was significantly decreased
and that was statistically significant. Overall survival of patients with
obesity was significantly longer (P=0.0270) than that of the patients with
BMI<30. Conclusion: In patients with BMI>30 high density of CAAs and high
number of CXCR4-positive cells in tumor may create specific tumor
microenvironment that prevent tumor cells to leave primary lesion. OS of
patients with gastric cancer is mainly influenced by CAAs density in tumors and
such influence depends essentially on the BMI.
Author(s) Details
Larissa Bubnovskaya
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.
Dr. Irina Ganusevich,
Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.
Sergej Merentsev
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.
Dr. Dmitry Osinsky
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/178
Author(s) Details
Larissa Bubnovskaya
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.
Dr. Irina Ganusevich,
Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.
Sergej Merentsev
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.
Dr. Dmitry Osinsky
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/178
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