Orotransmucosal Drug Delivery: An Emerging Approach for Treating Oral Mucosa Disease | Chapter 4 | Pharmaceutical Science: New Insights and Developments Vol. 6

Orotransmucosal drug delivery is an alternative method used for systemic drug delivery. It is used as a favoured route for non-parenteral administration of emergency drugs and agents. This route offers both advantages and limitations, notably the rich vascularisation of oral mucosal surfaces. It can be used both for lipid-soluble and water-soluble drugs. It increases drug solubility and reduces the permeability of the lipid bilayer membrane. Mucosal surfaces are often rich in blood supply, allowing for rapid drug transport into the systemic circulation and, in most cases, avoiding degradation by first-pass hepatic metabolism. These systems contact with absorbent surfaces improve absorption at the application site and increase dwell time. It involves several physiological features of the oral cavity. Technical difficulties and biological impediments can be used as broad categories to group oral administration issues. Orotransmucosal drug delivery system still faces some difficulties, such as pH, enzymatic activity and mucosal permeability. In this study, the mechanism of oral transmucosal administration of fentanyl citrate (OTFC) was examined. Orotransmucosal drug delivery system uses an absorption rate four times that of the skin. It is easily accessible and heals rapidly from trauma and injury. It has a smaller surface area than the skin and can only be exposed for brief periods of time. Thus, this delivery method is the best for medications with high therapeutic potency. Efficient orotransmucosal drug delivery can be achieved in the oral cavity's buccal, sublingual, palatal and gingival regions. Mastication or chewing food can improve or impair medication absorption in the oral cavity. Mucoadhesive drug delivery systems can be lost or damaged when used to fill chewing gum with drugs that are released when the chewing gum is chewed. to distribute active substances quickly and conveniently via the oral mucosa, QuickStripTM was created as a fast-disintegrating thin film matrix. This report also provides input for future orotransmucosal drug developments to treat oral mucosa diseases. Researchers aim to overcome permeability barriers, protect drugs from enzymes and consistently deliver effective doses using novel methods.

 

Author (s) Details

Hasan Mahmud
Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Farmgate, Dhaka -1205, Bangladesh.

 

Afnan Sayeid Himi
Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Farmgate, Dhaka -1205, Bangladesh.

 

Md. Muhtamim Hussain Rifat
Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Farmgate, Dhaka -1205, Bangladesh.

 

Md. Sohel Rana
Department of Pharmacy, Jahangirnagar University, Kalabagan Road, Savar, Dhaka - 1342, Bangladesh.

 

Khyam Radhifa Ritika
Department of Pharmacy, Stamford University Bangladesh, 51, Siddheswari Road, Ramna, Dhaka - 1217, Bangladesh.

 

Kazi Sanjida Alam Labonno
Department of Pharmacy, Stamford University Bangladesh, 51, Siddheswari Road, Ramna, Dhaka - 1217, Bangladesh.

 

Sunjida Akter
Department of Pharmacy, Stamford University Bangladesh, 51, Siddheswari Road, Ramna, Dhaka - 1217, Bangladesh.

 

Swarnali Islam
Department of Pharmacy, University of Asia Pacific, 74/A, Green Road, Farmgate, Dhaka -1205, Bangladesh.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v6/5533

Emphasizing the Mucoadhesive Buccal Drug Delivery System - An Unique Novel Drug Delivery System of the Modern Era | Chapter 1 | Technological Innovation in Pharmaceutical Research Vol. 2

 Mucoadhesive drug delivery systems have emerged as a unique novel drug delivery system in the modern scenario, owing to the current advent of Novel Drug Delivery Systems. In the area of Novel Drug Delivery Systems, the mucosal or mucoadhesive drug delivery system plays an important role as a revolutionary drug delivery system. In a more simplified sense, mucoadhesion refers to the adhesion of two materials to each other, one of which is the mucosal surface. Certain studies are underway to discover an alternative route that can circumvent hepatic metabolism, minimise dose frequency, and extend the duration of drug action. In those situations, drug delivery through the buccal cavity may be included in the real picture. Solids, semisolids, and clear drug-loaded films are among the dosage types of mucoadhesive drug delivery systems. As this comes into contact with the buccal mucous membrane, the drug continues to release in a sustained and regulated manner through the blood capillaries associated with the buccal cavity, ensuring optimum bioavailability and making drug administration easier. Increases treatment efficacy, improves patient compliance, and reduces dosage frequencies by bypassing hepatic portal systems and the gastrointestinal tract. Owing to the influx of new drug molecules as a result of drug development, mucoadhesive drug delivery will become much more critical in delivering these molecules.

Author (s) Details

Sayan Bhattacharjee
Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, SRIHER(DU), Porur, Chennai-116, India.

Dr. S. Nagalakshmi
Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, SRIHER(DU), Porur, Chennai-116, India.

S. Shanmuganathan
Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, SRIHER(DU), Porur, Chennai-116, India.

View Book :- https://stm.bookpi.org/TIPR-V2/issue/view/55

Injectable Multi-Drug Loaded Hydrogels for Contraception | Chapter 6 | New Ideas Concerning Science and Technology Vol. 5

 Without a liver first-pass reaction, injectable intravaginal hydrogels could deliver drugs systemically. Due to its wide surface area, rich blood supply, relatively high permeability of many medications, and self-insertion, the vaginal route has many benefits. This paper focuses on the contraceptive function of a four-arm star-shaped poly(D,L-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (4sPLGA-mPEG) injectable temperature-sensitive block of copolymer hydrogels as a carrier of three drugs. The cumulative release amounts of indomethacin (IMC), gestodene (GSD), and ethinyl estradiol (EE) from copolymer hydrogels could be regulated by adjusting the lactide/glycolide (LA/GA) mol ratio by investigating in vitro controlled release profiles through HPLC. In addition, the IMC, GSD, and EE in vitro release profiles were well in line with the Higuchi model. The acute toxicity of multi-drug copolymer hydrogels filled with different dosing contents was measured in vivo. The uterus was hydropic in the high-dose population on day 1 and ulcerated on day 5, followed by intestinal adhesion. No festering of the tissues was observed with respect to the middle dosage community and blood coagulum occurred on various days in the uterus. No major tissue necrosis was observed in the low dosage community. Finally, the antifertility tests confirmed the excellent contraceptive effect of hydrogels filled with the multi-drug. The above results showed that, as a multi-drug carrier, injectable copolymer hydrogel was promising as a novel form of contraception.

Author (s) Details

Lei Nie
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Meng Sun
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Peng Zou
Downhole Technology Service Company, Bohai Drilling Engineering Company Limited, CNPC, Dagang, Tianjin 300283, China.

Yanting Han
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Chingching Ji
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.

Qiuju Zhou
Analysis & Testing Center, Xinyang Normal University, Xinyang 464000, China.

Jinping Suo
State Key Laboratory of Mould Technology, Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

View Book :- https://stm.bookpi.org/NICST-V5/issue/view/22