Characterization and Preparation of New Injectable Regenerative Acellular Dermal Collagen Microparticles via a Designed Combined Procedure of Supercritical Fluids and Protease Treatments at Low Temperatures | Chapter 13 | Highlights on Medicine and Medical Science Vol. 17

 Tissue engineering, which combines medical applications with engineering materials, was crucial. The tissue and cellular molecules from pig skin were extracted using a pretreatment of supercritical fluids and a devised combined approach of supercritical fluids of carbon dioxide and protease treatments at low temperatures in this work. Using protease reagent treatments, different porosities of decellularized tissues were created. The author used supercritical fluid and protease reagent treatments to characterise the intended decellularized scaffolds obtained from pig skins.

Author (S) Details

Ching-Cheng Huang
Department of Biomedical Engineering, Ming-Chuan University, Taiwan, Republic of China and PARSD Pharmaceutical Technology Research Center (PBMRC), Taiwan, Republic of China.

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Injectable Multi-Drug Loaded Hydrogels for Contraception | Chapter 6 | New Ideas Concerning Science and Technology Vol. 5

 Without a liver first-pass reaction, injectable intravaginal hydrogels could deliver drugs systemically. Due to its wide surface area, rich blood supply, relatively high permeability of many medications, and self-insertion, the vaginal route has many benefits. This paper focuses on the contraceptive function of a four-arm star-shaped poly(D,L-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (4sPLGA-mPEG) injectable temperature-sensitive block of copolymer hydrogels as a carrier of three drugs. The cumulative release amounts of indomethacin (IMC), gestodene (GSD), and ethinyl estradiol (EE) from copolymer hydrogels could be regulated by adjusting the lactide/glycolide (LA/GA) mol ratio by investigating in vitro controlled release profiles through HPLC. In addition, the IMC, GSD, and EE in vitro release profiles were well in line with the Higuchi model. The acute toxicity of multi-drug copolymer hydrogels filled with different dosing contents was measured in vivo. The uterus was hydropic in the high-dose population on day 1 and ulcerated on day 5, followed by intestinal adhesion. No festering of the tissues was observed with respect to the middle dosage community and blood coagulum occurred on various days in the uterus. No major tissue necrosis was observed in the low dosage community. Finally, the antifertility tests confirmed the excellent contraceptive effect of hydrogels filled with the multi-drug. The above results showed that, as a multi-drug carrier, injectable copolymer hydrogel was promising as a novel form of contraception.

Author (s) Details

Lei Nie
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Meng Sun
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Peng Zou
Downhole Technology Service Company, Bohai Drilling Engineering Company Limited, CNPC, Dagang, Tianjin 300283, China.

Yanting Han
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China and Henan Key Laboratory of Tea Plant Biology, Xinyang Normal University, Xinyang 464000, China.

Chingching Ji
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.

Qiuju Zhou
Analysis & Testing Center, Xinyang Normal University, Xinyang 464000, China.

Jinping Suo
State Key Laboratory of Mould Technology, Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

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